Palmitoylethanolamide! Only formulations containing PEA-m, PEA-um and PEA-opt have been extensively and since many years clinically been tested for safety and efficacy.
Only Pea-opt, PEA-um and PEA-m formulations are proven to generate increases in PEA levels in our blood after oral intake!
Only Epitech (producing PEA-um and PEA-m formulations, and Russell Science (producing PEA-opt formulations) have tested palmitoylethanolamide since many years under the supervision of physicians and specialists. In Italy palmitoylethanolamide has been introduced around 2007, and in the Netherlands around 2010.
Meanwhile many thousands of patients have been treated with these Italian and Dutch formulations, most probably more million patients, including many elderly patients.
Neither Epitech, nor Russell Science ever monitored a serious side effect.
Quality of Palmitoylethanolamide in reliable products
The quality of Epitech products is easy to follow: the products all are produced based on patented procedures leading to micronized palmitoylethanolamide (PEA-m) and ultramicronized palmitoylethanolamide (PEA-um). If one obtains palmitoylethanolamide tablets or palmitoylethanolamide sachets, NOT containing PEA-m or PEA-um, one makes a choice for clinically untested formulations. These can be cheap ripp-offs and formulations not tested during years on safety and efficacy under medical guidance.
The quality of the Russell Science products is also easy to follow: the products all have obtained the quality marker PEA-opt, and the production is also based on a standardized and patented production processes. If one obtains palmitoylethanolamide capsules or NOT containing PEA-opt, one mostly obtains cheap ripp-offs, formulations not tested during years on safety and efficacy under medical guidance.
Both PEA-m, PEA-um and PEA-opt are all tested for efficacy and safety in the hands of experienced physicians.
The quality of PEA in the products of both companies has been found to be safe and effective, and the results of clinical testing has been documented in many different scientific and medical journals.
New Palmitoylethanolamide tablets and capsules: warnings
Because of the high potential of palmitoylethanolamide, since 2014 we have seen new and cheap palmitoylethanolamide capsules and tablets entering the marketplace. These have been produced by companies without any know how of this special product and no experience. It was Epitech who first warned on their website for such products:
“Patients buying, via e-commerce, formulations containing highly impure, unmicronized palmitoylethanolamide produced in China, are at serious risk from an unregulated product entirely unsuitable for systemic use in humans…”
In order to bring palmitoylethanolamide formulations to the client, new companies ordered palmitoylethanolamide in the Far East at factories which do not have their own production facility. If these companies get an order from a Western producer of supplements, these Far East companies find a little class B factory to produce only one batch for them, and this of course cannot ensure the quality nor the stability of the product.
Moreover, the production of palmitoylethanolamide in such facilities follows chemical synthesis procedures where solvents are used and residues of these toxic solvents may stay in the final product.
Furthermore, there are companies in the Far East who fill capsules with white powder and bring counterfeit material to the customer.
The quality of most of the palmitoylethanolamide is quite low, as the production of this compound initially was for cosmetic purposes only and not for human consumption. And even these cosmetic products follow a synthesis proces which is quite unfit for human consumption. Low quality of product leads to a low price, and this translates into cheap palmitoylethanolamide products offered to the patient.
There are now to many small producers of palmitoylethanolamide and this makes it not easy for the uninformed customer to decide what product to take.
Recommendation: PEA products with proven safety and efficacy
We therefore recommend to chose products with a long track of clinical use, and documented safety and efficacy. These are as far as we know the products containing PEA-m, PEA-um or PEA-opt, produced respectively by Epitech group in Italy and the Russell Science group, produced in the Netherlands.