Eye disorders: Relevance of Palmitoylethanolamide

The eye consists of a number of tissues, such as the retina, the uvea, and much more. In various experiments the supplemente palmitoylethanolamide proved that it can protect the eye.



Palmitoylethanolamide can also protect our eyes (especially the sensitive light-monitoring retina celles, against neurodegeneration as well as against high intraocular pressure, such as in glaucoma.
In this section we will review a number of trials related to the effiacy of palmitoylethanolamide in eye disorders.

The dose to use in eye disorders is 2-3 times daily 400 mg PEA as for instance in PeaPure.


The anti-inflammatory effects of palmitoylethanolamide (PEA) on endotoxin-induced uveitis in rats.
Impellizzeri D, Ahmad A, Bruschetta G, Di Paola R, Crupi R, Paterniti I, Esposito E, Cuzzocrea S.
Eur J Pharmacol. 2015 Apr 28. pii: S0014-2999(15)00369-6. doi: 10.1016/j.ejphar.2015.04.025. [Epub ahead of print]

N-Palmitoylethanolamine depot injection increased its tissue levels and those of other acylethanolamide lipids.
Grillo SL, Keereetaweep J, Grillo MA, Chapman KD, Koulen P.
Drug Des Devel Ther. 2013 Aug 12;7:747-52. doi: 10.2147/DDDT.S48324. eCollection 2013.

Effects of palmitoylethanolamide on aqueous humor outflow.
Kumar A, Qiao Z, Kumar P, Song ZH.
Invest Ophthalmol Vis Sci. 2012 Jul 3;53(8):4416-25. doi: 10.1167/iovs.11-9294.

Palmitoylethanolamide effects on intraocular pressure after Nd:YAG laser iridotomy: an experimental clinical study.
Pescosolido N, Librando A, Puzzono M, Nebbioso M.
J Ocul Pharmacol Ther. 2011 Dec;27(6):629-35. doi: 10.1089/jop.2010.0191. Epub 2011 Aug 10.
PMID: 21830944
Related citations
Select item 21779318
Administration of URB597, oleoylethanolamide or palmitoylethanolamide increases waking and dopamine in rats.
Murillo-Rodríguez E, Palomero-Rivero M, Millán-Aldaco D, Arias-Carrión O, Drucker-Colín R.
PLoS One. 2011;6(7):e20766. doi: 10.1371/journal.pone.0020766. Epub 2011 Jul 14.

First clinical case of effective medical treatment of the vitreoretinal traction with recovery of the visual acuity.
Pescosolido N, Puzzono M.
Clin Ter. 2010;161(4):e143-7.

Changes in endocannabinoid and palmitoylethanolamide levels in eye tissues of patients with diabetic retinopathy and age-related macular degeneration.
Matias I, Wang JW, Moriello AS, Nieves A, Woodward DF, Di Marzo V.
Prostaglandins Leukot Essent Fatty Acids. 2006 Dec;75(6):413-8. Epub 2006 Oct 2.

Finding of endocannabinoids in human eye tissues: implications for glaucoma.
Chen J, Matias I, Dinh T, Lu T, Venezia S, Nieves A, Woodward DF, Di Marzo V.
Biochem Biophys Res Commun. 2005 May 20;330(4):1062-7.

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