PEA in Klinische Studien: Ueberblick

Klinische Studien: Wirksamkeit und Vertraeglichkeit PEA in Chronische Schmerzsyndrome

Der natürliche Wirkstoff Palmitoylethanolamid ist ein Durchbruch in der Behandlung von chronischen Schmerzen. Es ist als PeaPure produziert in den Niederlanden. Es wird auch in Italien unter dem Namen Normast produziert.

PEA in allgemeine Schmerzsyndrome

DiPaolo A et al. Palmitoylethanolamide as a treatment for vaious chronic painstates. Presented at the 34 AISD congress in Riccione, 2011 |

Desio P, Pregabalin and Palmitoylethanolamide in the treatment of neuropathic pain. Pathos 2010l17:9-14 |

PEA in Schmerz bei Costen Syndrom (TMJD)

Bortolotti F,Russo M, Bartolucci ML, Alessandri Bonetti G, Gatto MR, Marini I. Palmitoylethanolamide vs NSAID in the treatment of TMJD Pain | Journal of Dental Research | 2010: 89(Special Issue B)

PEA in chronischer Rueckenschmerzen (Bandscheibe Vorfall)

G. Guida, A. de Fabiani, F. Lanaia, A. Alexandre, G.M. Vassallo, L. Cantieri, M. de Martino, M. Rogai, S. Petrosino | La palmitoiletanolamida (Normast) en el dolor neuropatico cronico por lumbociatalgia de tipo compresivo: estudio clinico multicentrico. Dolor 2010, 25:35-42

Desio,P et al. | Efficacy of palmitoylethanolamide and oxycodon in patients with low back pain. Anesthesia and medicina critica (AMC) 2011, 2: 62-71.

Canteri L et al. Reduction of analgesics in patients suffering from lumbosciatic pain, treated with palmitoylethanolamide. Dolor 2010 | 25:227-234 |

Palomba R et al. | Efficacy of palmitoylethanolamide as part of multimodal analgesic therapy in patients with low back pain. Presented at 33rd AISD congress, 2010, Florence |

Dominguez CM et al. Palmitoylethanolamide on standard care in lumbosciatic pain, a pragmatic trial. Preseted at 8th congres of Pain algologists, Madrid, 2010. : discussed on the next movie

PEA in Karpal Tunnel Syndrom

Assini A, Laricchia D, Pizzo R, Pandolfini L, Belletti M, Colucci M, Ratto S. | P1577: The carpal tunnel syndrome in diabetes: clinical and electrophysiological improvement after treatment with palmitoylethanolamide | Eur J Neurol | 2010: 17(S3):295.

Conigliaro R, Drago V, Foster PS, Schievano C, Di Marzo V. | Use of palmitoylethanolamide in the entrapment neuropathy of the median in the wrist. | Minerva Med. | 2011 Apr;102(2):141-7.

PEA in Schmerzhafte Neuropathie

Biasiotta A, La Cesa S, Leone C, Di Stefano G, Truini A, Cruccu G. | Efficacy of palmitoylethanolamide in patients with painful neuropathy. A clincial and neurophysiological open study. Preliminary results. | , Volume 4, Issue 1, May 2010, Page 77.

Deslo. P. Combination of pregabalin and palmitoylethanolamide (PEA) for neuropathic pain treatment. | Pathos, 2010, 17,4:9-14

Calabrò RS, Gervasi G, Marino S, Mondo PN, Bramanti P. | Misdiagnosed chronic pelvic pain: pudendal neuralgia responding to a novel use of palmitoylethanolamide. | Pain Med. | 2010 May;11(5):781-4. Epub 2010 Mar 22.

Jorge LL, Feres CC, Teles VE. | Topical preparations for pain relief: efficacy and patient adherence. | J Pain Res. | 2010 Dec 20;4:11-24.

PEA in diabetische Symptome unde Schmerzen

Schifiliti C, et al. Efficacy of palmitoylethanolamide in pain and neuropathic symptoms in diabetic patients. Presentation at IV congress of European Schock society, Taormina, 2011

Adiletta S et al. Pregabalin and Palmitoylethanolamide in diabetic neuropathic pain: an randomized clinical trial. Presented at the 34th AISD meeting, 2011, Riccione. | Reported

PEA in neuropathische Schmerzen in MS

Mancardi GL et al. Palmitoylethanolamide in neuropathic pain in MS patients. Presented at the 15yh Italian neurological meeting in Padua, 2009 |

PEA in chemo-induzierte neuropathische Schmerz

Truina A et al. Palmitoylethanolamide improves pain and nerve function in patients suffering from chemotherapy induced neuropathy. CNS and neurological drug target, 2011, submitted. |

Palmitoylethanolamide creme in postherpetische Schmerz

Phan NQ, Siepmann D, Gralow I, Ständer S. | Adjuvant topical therapy with a cannabinoid receptor agonist in facial postherpetic neuralgia. | J Dtsch Dermatol Ges. | 2010 Feb;8(2):88-91. Epub 2009 Sep 10.

PEA in Pelvische Schmerzen

Indraccolo U, Barbieri F. | Effect of palmitoylethanolamide-polydatin combination on chronic pelvic pain associated with endometriosis: preliminary observations. | Eur J Obstet Gynecol Reprod Biol. | 2010 May;150(1):76-9. Epub 2010 Feb 21.

Calabrò RS, Gervasi G, Marino S, Mondo PN, Bramanti P. | Misdiagnosed chronic pelvic pain: pudendal neuralgia responding to a novel use of palmitoylethanolamide. | Pain Med. | 2010 May;11(5):781-4. Epub 2010 Mar 22.

Keppel Hesselink JM. | Effectiveness of the association micronized N-palmitoylethanolamine (PEA)-transpolydatin in the treatment of chronic pelvic pain. | Eur J Obstet Gynecol Reprod Biol. | 2011 Jul 14.

Fulghesu A et al. Pain during menstruation in young adults treated with palmitoylethanolamide and polidatina. Presented at the 16th world congress for child and adolescent gynaecology, Montpellier, 2010 |

Murina F. et al. Palmitoylethanolamide and polidatina in the treatment of vestibulodynia, and the reduction of the C fibre activation. Presented at the world congress of pathology of the vulva, Parigi, september 2011 |

PEA in Zahmedizin

Christian Bacci, Giulia Cassetta, Bruno Emanuele, and Mario Berengo | Research Article Randomized Split-Mouth Study on Postoperative Effects of Palmitoylethanolamide for Impacted Lower Third Molar Surgery | Volume 2011: Article ID 917350, 6 pages doi:10.5402/2011/917350

PEA cream in Dermatologie

Eberlein B, Eicke C, Reinhardt HW, Ring J. | Adjuvant treatment of atopic eczema: assessment of an emollient containing N-palmitoylethanolamine (ATOPA study). | J Eur Acad Dermatol Venereol. | 2008 Jan;22(1):73-82.

Kircik L. | A nonsteroidal lamellar matrix cream containing palmitoylethanolamide for the treatment of atopic dermatitis. | J Drugs Dermatol. | 2010 Apr;9(4):334-8.

Pulvirenti N, Nasca MR, Micali G. | Topical adelmidrol 2% emulsion, a novel aliamide, in the treatment of mild atopic dermatitis in pediatric subjects: a pilot study. | Acta Dermatovenerol Croat. | 2007;15(2):80-3.

Petrosino S, Cristino L, Karsak M, Gaffal E, Ueda N, Tüting T, Bisogno T, De Filippis D, D’Amico A, Saturnino C, Orlando P, Zimmer A, Iuvone T, Di Marzo V. | Protective role of palmitoylethanolamide in contact allergic dermatitis. | Allergy. | 2010 Jun 1;65(6):698-711. Epub 2009 Nov 11.

Kemeny L, Koreck A, Kis K, Kenderessy-Szabo A, Bodai L, Cimpean A, Paunescu V, Raica M, Ghyczy M. | Endogenous phospholipid metabolite containing topical product inhibits ultraviolet light-induced inflammation and DNA damage in human skin. | Skin Pharmacol Physiol. | 2007;20(3):155-61. Epub 2007 Jan 17.

PEA in glaucoma and Augenheilkunde

Pescosolido N, Librando A, Puzzono M, Nebbioso M. | Palmitoylethanolamide Effects on Intraocular Pressure After Nd:YAG Laser Iridotomy: An Experimental Clinical Study. | J Ocul Pharmacol Ther. | 2011 Aug 10.

Caterina Gagliano et al | Ocular hypotensive effect of oral palmitoylethanolamide: a clinical trial. | Invest. Ophthalmol. Vis. Sci. June 24, 2011 iovs.10-7057 |

Pescosolido N, Puzzono M. | First clinical case of effective medical treatment of the vitreoretinal traction with recovery of the visual acuity. | Clin Ter. | 2010;161(4):e143-7.




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