Palmitoylethanolamide modulates T-cell- mast cell interaction


The mast cell can be inhibited by PeaPure in IC

The mast cell can be inhibited by pure PEA

At the 34° Congresso Nazionale della Società Italiana di Farmacologia in Rimini, Pala-congressi, 14-17 Ottobre 2009,  Marta Valenti and colleagues presented data on the ROLE OF PALMITOYLETHANOLAMIDE ON MODULATION OF THE MAST CELL-T CELL INTERACTIONS: AN IN VITRO STUDY.

They analyzed supernatants obtained from co-culturing (human mast cells and activated Jurkat T cells with different concentrations of PEA (nM range) or its vehicle, for released IL-8.

PEA was able to decrease the amount of released IL-8 (~ 45%) in a concentration-independent manner.

To analyse whether PEA was able to interact per se with mast cells or T cells activity, the authors performed experiments in which HMC-1 or activated Jurkat T cells were treated with PEA before carrying out co-cultures.

There was no differences in IL-8 release when supernatants from pre-treated HMC-1 co-cultured with activated Jurkat T cells were analyzed, but, surprisingly, a decrease by 75% was observed in supernatants obtained from pre-treated Jurkat T cells and HMC-1. The CB2 receptor was not involved in PEA effects as demonstrated by the inefficacy of SR144528 antagonist in reverting the IL-8 inhibition.

These results suggest that PEA can effectively modulate the mast cells-T cell interaction, corroborating its valuable anti-inflammatory efficacy.

Study was sponsored by Epitech


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