Palmitoylethanolamide is recommended to use in a pure form. In this recently published paper, the disadvantages of various PEA formulations compared to pure PEA. The author concludes and we quote:
Based on additional studies discussed in this commentary and in view of the effects of ultra-micronization on the parameters discussed, as well as the potential side-effects of additives such as excipients and herbal extracts added to the products cited in the article, the preference should be for the time being to treat patients with pure PEA without any of these additives.
1. Critical Paper:
Rutger Kriek. Palmitoylethanolamide: problems regarding micronization, ultra-micronization and additives. Inﬂammopharmacol february 2014; DOI 10.1007/s10787-014-0202-3
2. Original paper: Skaper SD1, Facci L, Fusco M, Della Valle MF, Zusso M, Costa B, Giusti P. Palmitoylethanolamide, a naturally occurring disease-modifying agent in neuropathic pain. Inflammopharmacology. 2014 Apr;22(2):79-94. doi: 10.1007/s10787-013-0191-7. Epub 2013 Nov 1.