Palmitoylethanolamide: high in certain brain parts en metabolism via FAAH

PEA levels in brain

PEA levels in brain

dr. Lipud from the Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky and colleagues assessed PEA levels in brain with and without the use of a FAAH inhibitor. The results were striking. PEA content was highest compared to related molecules and the level increased significantly. The authors pointed out:

This is the first study to demonstrate brain region and compound specific alterations in eCB and NAE content following a single dose of URB597.

Source: Liput DJ, Tsakalozou E, Hammell DC, Paudel KS, Nixon K, Stinchcomb AL. Quantification of anandamide, oleoylethanolamide and palmitoylethanolamide in rodent brain tissue using high performance liquid chromatography-electrospray mass spectroscopy. J Pharm Anal. 2014 Aug;4(4):234-241.

Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Google+ photo

You are commenting using your Google+ account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

%d bloggers like this: