Eye disorders: Relevance of Palmitoylethanolamide

The eye consists of a number of tissues, such as the retina, the uvea, and much more. In various experiments the supplemente palmitoylethanolamide proved that it can protect the eye.

Palmitoylethanolamide-Treat-Glaucoma

Palmitoylethanolamide-Treat-Glaucoma

Palmitoylethanolamide can also protect our eyes (especially the sensitive light-monitoring retina celles, against neurodegeneration as well as against high intraocular pressure, such as in glaucoma.
In this section we will review a number of trials related to the effiacy of palmitoylethanolamide in eye disorders.

The dose to use in eye disorders is 2-3 times daily 400 mg PEA as for instance in PeaPure.

Literature:

The anti-inflammatory effects of palmitoylethanolamide (PEA) on endotoxin-induced uveitis in rats.
Impellizzeri D, Ahmad A, Bruschetta G, Di Paola R, Crupi R, Paterniti I, Esposito E, Cuzzocrea S.
Eur J Pharmacol. 2015 Apr 28. pii: S0014-2999(15)00369-6. doi: 10.1016/j.ejphar.2015.04.025. [Epub ahead of print]

N-Palmitoylethanolamine depot injection increased its tissue levels and those of other acylethanolamide lipids.
Grillo SL, Keereetaweep J, Grillo MA, Chapman KD, Koulen P.
Drug Des Devel Ther. 2013 Aug 12;7:747-52. doi: 10.2147/DDDT.S48324. eCollection 2013.

Effects of palmitoylethanolamide on aqueous humor outflow.
Kumar A, Qiao Z, Kumar P, Song ZH.
Invest Ophthalmol Vis Sci. 2012 Jul 3;53(8):4416-25. doi: 10.1167/iovs.11-9294.

Palmitoylethanolamide effects on intraocular pressure after Nd:YAG laser iridotomy: an experimental clinical study.
Pescosolido N, Librando A, Puzzono M, Nebbioso M.
J Ocul Pharmacol Ther. 2011 Dec;27(6):629-35. doi: 10.1089/jop.2010.0191. Epub 2011 Aug 10.
PMID: 21830944
Related citations
Select item 21779318
5.
Administration of URB597, oleoylethanolamide or palmitoylethanolamide increases waking and dopamine in rats.
Murillo-Rodríguez E, Palomero-Rivero M, Millán-Aldaco D, Arias-Carrión O, Drucker-Colín R.
PLoS One. 2011;6(7):e20766. doi: 10.1371/journal.pone.0020766. Epub 2011 Jul 14.

First clinical case of effective medical treatment of the vitreoretinal traction with recovery of the visual acuity.
Pescosolido N, Puzzono M.
Clin Ter. 2010;161(4):e143-7.

Changes in endocannabinoid and palmitoylethanolamide levels in eye tissues of patients with diabetic retinopathy and age-related macular degeneration.
Matias I, Wang JW, Moriello AS, Nieves A, Woodward DF, Di Marzo V.
Prostaglandins Leukot Essent Fatty Acids. 2006 Dec;75(6):413-8. Epub 2006 Oct 2.

Finding of endocannabinoids in human eye tissues: implications for glaucoma.
Chen J, Matias I, Dinh T, Lu T, Venezia S, Nieves A, Woodward DF, Di Marzo V.
Biochem Biophys Res Commun. 2005 May 20;330(4):1062-7.

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