Palmitoylethanolamide reduces inflammatory phenotypes of glia

Francesca Guida presented data at the 36° CONGRESSO NAZIONALE DELLA SOCIETÀ ITALIANA DI FARMACOLOGIA; Il ruolo della RICERCA farmacologica per la CRESCITA e la SALUTE in Italia, Torino, 23-26 ottobre 2013:

Palmitoylethanolamide reduces formalin-induced neuropathic-like behaviour through spinal glial/microglial phenotypical changes in mice.

In the presentation Guida described Palmitoylethanolamide (PEA) as a potent modulator of several functions in different pathological states, such as inflammation and pain response. One co-author was M. Fusco, employee of Epitech Srl, the producer of Normast (paper had however no no comflict of interest section).

The effects of PEA (5-10 mg/kg) was described on mechanical allodynia and thermal hyperalgesia 3 and 7 days following
peripheral injection of formalin. Furthermore, and quite new, the researcher explored the PEA effect on the glial/microglial phenotypical changes associated with spinal neuronal sensitization.

The results were impressive:

1. In vivo electrophysiology revealed a significant increase of the duration and frequency, and a rapid decrease in the onset of evoked activity of the spinal nociceptive neurons 7 days after formalin. PEA normalized this in a
dose-dependent manner.
2. Formalin induced a significant microglia and glia activation and this could be normalized by PEA.

The conclusion was:

PEA has potent anti-inflammatory and anti-allodynic effect of PEA, possibly via microglial/glial cells at spinal cord level.

Source: F. Guida, L.Luongo, S. Boccella,G. Bellini,L. Gatta, F. Rossi,V. de Novellis,S. Maione. Palmitoylethanolamide reduces formalin-induced neuropathic-like behaviour through spinal glial/microglial phenotypical changes in mice. Presented data at the 36° CONGRESSO NAZIONALE DELLA SOCIETÀ ITALIANA DI FARMACOLOGIA; Il ruolo della RICERCA farmacologica per la CRESCITA e la SALUTE in Italia, Torino, 23-26 ottobre 2013.

2013-Guida-Palmitoylethanolamide reduces formalin-induced neuropathic-like behaviour through spinal glial:microglial phenotypical changes in mice

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