In the Journal of Urology pharmacologists have proven that palmitoylethanolamide (PEA) protects the bladder against inflammation. This adds to the many clinical and experimental data supporting palmitoylethanolamide as an important natural protector for cells in crisis, such as during inflammation. Other animal studies have shown that PEA exerts therapeutically-relevant analgesic and neuroprotective effects as well. PEA is an endogenous mediator produced during
pathophysiological states to attenuate inflammation, neuronal damage and pain.
The objective of the present study was to address the potential use of PEA to alleviate experimental cystitis. PEA is already widely in use for the treatment of the chronic bladder syndrome (in Italy and the Netherlands) and it alleviates chronic pain as well as the other signs of inflammation.
Together with other (older) data the results support to the beneficial effect of PEA on bladder function. The endogenous levels of PEA were increased in response to acute bladder inflammation, clearly pointing out the protective effects the body tries to achieve by the synthesis of this molecule.
The findings of this group and described in the study we here discuss, indicate that the naturally occurring molecule PEA is elevated in the bladder in response to an inflammatory insult and exerts beneficial effects in experimental cystitis when given exogenously.
Pessina F, Capasso R, Borrelli F, Aveta T, Buono L, Valacchi G, Fiorenzani P, Di Marzo V, Orlando P, Izzo AA. Protective effect of palmitoylethanolamide, a naturally-occurring molecule, in a rat model of cystitis. J Urol. 2014 Nov 18. pii: S0022-5347(14)04930-1. doi: 10.1016/j.juro.2014.11.083.