There is a field of lipid/fatty acid research I recently started to read about. it hopefully helps with pain, inflammation and “increased resistance against infections”.
First what is a nuclear receptor? Nuclear receptors are a class of proteins found within cells that are responsible for sensing steroid and thyroid hormones and certain other molecules. In response, these receptors work with other proteins to regulate the expression of specific genes, thereby controlling the development, homeostasis (balance), and metabolism of the organism. (Wikipedia)
Palmitoylethanolamide/PAE binds to a nuclear receptor in the cell-nucleus and exerts a great variety of biological functions related to chronic pain and inflammation. It is now being used for pain and inflammation. It does seem to have a long history, but for immunity purposes much earlier. I suggest you view Hasselink’s video in the link to Evolutions in Pharmacological Thinking. (There are two more videos further down in my post.)
In that video he mentions Dr Rita Levi-Montalcini, and in this linked review he writes that she “was awarded the Nobel prize for her work on the role nerve growth factor (NGF)36 in inflammation and its activating role in mast cells, showing that positive feedback of NGF on mast cell behavior could be modulated and inhibited by PEA. This was the first explanation of how PEA could inhibit inflammation.”
AVAILABILITY —– —– AVAILABILITY —– —–
“Since 2008, PEA has been marketed as a food for special medical purposes in Italy and Spain, under the brand name Normast (Epitech Srl). Recently, a food-supplement named PeaPure was introduced (JP Russell Science Ltd.). In the USA, PEA is under evaluation as a nutraceutical for inflammatory bowel syndrome (proposed brand name Recoclix, CM&D Pharma Ltd.; Nestl).”http://www.hindawi.com/journals/iji/2013/151028/
—–I haven’t done a thorough look at the topic of availability, but I saw this, which you don’t have to read, but it shows that more docs using it. A San Diego, CA, USA physician, and a source is given–it’s imported to a local pharmacy. http://painsandiego.com/tag/palmitoylethanolamide/