About: focus on PEA and professor Rita Levi-Montalcini’s work

Tribute to Rita Levi-Montalcini

Tribute to Rita Levi-Montalcini

This Site is dedicated to the work of Nobel price winner professor Rita Levi-Montalcini (1909-2012), and especially related to palmitoylethanolamide (PEA). Levi-Montalcini was the first to unravel the mechanism of action of PEA.

Rita Levi-Montalcini at 101 years old

Rita Levi-Montalcini at 101 years old

It is a chapter from the work of a circle of dedicated scientists and physicians, wanting to revolutionize medicine via the activation of natural healing pathways in our body.  This coalition has a specific mission, to inform patients and therapists/physicians about side effect free natural pharmacological treatments of chronic pain.

This website has been designed by concerned scientists, biologists and MDs, to compensate for the overwhelming information of marketed analgesics or painkillers by pharmaceutical companies.

All these branded painkillers are very well known to doctors who are trained in prescribing these. Much less is known about natural alternatives such as nutraceuticals.

This Site is focussing on such a natural remedy, not supported by drug industry, because the molecules we discuss, in this case palmitoylethanolamide, as a natural molecule cannot be protected by patents. The interest from the pharmaceutical industry for palmitoylethanolamide therfore is ziltch. Even so although a Nobel price laureate discovered its mechanism of action.

We hope this site will help pain-sufferers, by bringing the focus on this natural painkiller, a molecule we produce in our own body, palmitoylethanolamide (PEA).

The efficacy and safety of this natural compound has been documented  in many clinical, double blind trials in around 5000+ patients.

Since the early 70s more than million patients have been treated and PEA is free from troublesome side-effects, and can be administered together with any other drug or painkiller.

Because PEA is a natural painkillers and a breakthrough in pain medicine, we want to help many sufferers from chronic pain via the information on this site. This site is NOT written by a pharmaceutical industry, but as said, by concerned physicians and scientific friends.

PEA is available as nutraceuticals under several brandnames: Pelvilen (consists of 49% of PEA), Pelvilen Forte (60% PEA), Normast sachets (60% PEA), Normast tablets (68% PEA), Visimast (68% PEA), Achilles (12% of PEA) and PeaPure (100% PEA).

PEA in Normast, Pelvilen, peaPure, Achilles

Some other natural molecules we are exploring are L-theanine (calming, sleep), alpha-lipoic acid (support in diabetes) and acetyl-l-carnitine (protects nerves).

This site is therefore also dedicated to our topic: palmitoylethanolamide, a molecule explored and discussed as a breakthrough by Nobel price winner professor Rita Levi-Montalcini (1909-2012) for the treatment of inflammatory, auto-immune disorders and chronic pain.

In the section professoressa explains you will find a number of cartoons were Levi-Montalcini explains the key scientific facts related to palmitoylethanolamide.

Due to the fact that we believe in the spread if information independent of language, we tried constructing a multilinguistic website: English, German, French, Dutch, Spanish and Italian.

Palmitoylethanolamide: classification, safety, efficacy and body of evidence

Palmitoylethanolamide is available for patients as a nutraceutical. The two leading brands Normast and PeaPure both contain palmitoylethanolamide. Nutraceuticals can be classified as either a diet supplement, or as food for medical purposes. The significance of both products is the optimal balance between proven and documented efficacy and safety. Normast and PeaPure are the only nutraceuticals, tested and discussed in more than 400 scientific articles. The body of evidence for its efficacy and safety is overwhelmingly stronger compared to whatever other product in this catagory, reviews in:

1. Keppel Hesselink, J.M. 2012. New Targets in Pain, Non-Neuronal Cells, and the Role of Palmitoylethanolamide. Open Pain Journal 5: 12-23

2. Keppel Hesselink, J.M., Hekker, T.A. 2012. Therapeutic utility of palmitoylethanolamide in the treatment of neuropathic pain associated with various pathological conditions: a case series Journal of Pain Research 5:437 – 442

3. Keppel Hesselink JM, Kopsky DJ, Treatment of chronic regional pain syndrome type 1 with palmitoylethanolamide and topical ketamine cream: modulation of nonneuronal cells. Journal of Pain Research 2013

4. Keppel Hesselink, J M,  Tineke de Boer, and Renger F. Witkamp. Review Article. Palmitoylethanolamide: A Natural Body-Own Anti-Inflammatory Agent, Effective and Safe against Influenza and Common ColdInternational Journal of Inflammation Volume 2013 (2013), Article ID 151028, 8 pages http://dx.doi.org/10.1155/2013/151028

5. Keppel Hesselink JM. Chronic idiopathic axonal neuropathy and pain, treated with the endogenous lipid mediator palmitoylethanolamide: a case collection. International Medical Case Reports Journal Published Date September 2013 Volume 2013:6 Pages 49 – 53

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