Palmitoylethanolamide (PeaPure): use of a natural painkiller

Natural Treatment of Pain is Possible with Palmitoylethanolamide

Natural Treatment of Pain is Possible with Palmitoylethanolamide

Natural Painkiller: Palmitoylethanolamide (PEA), take home message

A very special molecule, produced in our own body, and now available as supplement (PeaPure and the new PeaPlex) and as cream (PEA cream),  as wel as dietfood for medical purposes in Italy and Spain (Normast).

PEA has been explored since 1957 and has a clear analgesic and anti-inflammatory efficacy, and virtually no side effects. Meanwhile within the context of clinical trials 5000 patients have been using PEA, and its efficacy and safety has been documented in more than 500 scientific papers. Under this link the most comprehensive proof of PEA’s efficacy (with the Numbers Needed to Treat of 1.5).

Since 2012 it is also available in the USA/Canada and it is shipped to the the USA/Canada via the Netherlands. We regularly receive questions from those countries on how to obtain and use PEA. Meanwhile there are many hundreds of satisfied US/Canadian citizens using this natural painkiller. PEA is available as capsules PeaPure of 400 mg (step in dose: take 1200 mg daily), as enriched capsules PeaPlex, and as PEA cream. PEA can be combined without any difficulties with any other drug, painkiller or supplement. Supplementation with PEA encourages the body’s own natural healing and painkilling capacity to do its thing. Since 2014 there is also available a new PEA cream, to enhance the effects of PEA also via the thin nerves in the skin.

Reach us with questions and remarks related to PEA on, and help us to construct the biggest database ever on this remarkable molecule.


  1. painkiller and anti-inflammatory compound
  2. produced in our cells, natural compound
  3. protects cells
  4. is proven to be effective and safe in many clinical trials in more than 5000 patients
  5. can be combined with any other compound
  6. is available as capsules and as cream

PEA: safety, efficacy and purity, further details

Very few side effects are reported, and this painkiller is also easy to combine with all kinds of other medication and analgesics, and is proven to be effective in many chronic pain states. The efficacy of PEA is impressive, expressed as Numbers Needed to Treat (NNT) is 1.5 for sciatic pain (based on a full powered double blind, placebo controlled trial). Numbers Needed to Treat is the most up to date way to express efficacy, and the NNT of 1.5 means one needs to treat 3 patients with severe pain, to help 2 to find adequate pain reduction. Most painkillers have NNT of 2-6 (Meaning one has to treat 2 to 6 patients to help one…).

In table 1 we see the efficacy of PEA compared to many other painkillers. There is one issue to understand, because PEA modulates via various natural mechanisms of the body, the analgesic effects are build up day by day; most people notice the effects within 1 week, but sometimes 6-8 weeks is required, especially for chronic pain syndromes. To reset the system the molecule needs some time.

Pijnstillers, waaronder PeaPure en de sterkte van de pijnstilling als NNT

Table 1. Painkillers and PeaPure, efficacy according to Numbers Needed to Treat, NNT

PeaPure is documented  with a certificate of analysis for review and is produced according to the highest standards of GMP. In addition to PeaPure there are a number of other PEA containing products, but these all have a much lower % of PEA per serving, and to date, certificates of analysis are not available for these products to review.

There are also uncertified PEA supplements available (especially in the USA) containing herbal material of unknown origin. Recently there was an analysis of all PEA products, and the conclusion wast: the preference should be for the time being to treat patients with pure PEA without any of these additives. (Kriek, 2014)

PEA products such as PeaPure and PEA cream are based on a totally new therapeutic principle, based on activation of our own natural systems. This is due to the fact that the active principle in PeaPure is palmitoylethanolamide (PEA).

Nobel price winner Professor Rita Levi-Montalcini discovered the mechanism of action of PEA

The mother of the PEA principle is the Nobel laureate professor Rita Levi-Montalcini. In a separate section she will explain in a number of cartoons the essence of palmitoylethanolamide.

PEA is a body-own fatty compound, and is produced by our own living cells to restore balance in chronic pain and chronic inflammation. Its anti-inflammatory and painkilling properties are known in science many decades since the first description of this compound in 1957. in 1993 the Nobel price winner professor Rita Levi-Montalcini pointed out the relevance of PEA for medicine and since then more than 300 scientific papers on PEA have been published. She also was the first person discovering the mechanism of action of PEA. She worked with PEA in its purest version.

Rita Levi-Montalcini

Rita Levi-Montalcini, MD, PhD, Nobel laureate

Many of the scientific data related to palmitoylethanolamide are discussed at this site in order to enrich modern medicine with more insight in the properties and the value of this all natural painkiller and anti-inflammatory compound. In references 1-5 you will find free PDF’s in peer reviewed journals summerizing all clinical data of palmitoylethanolamide.

5000 patients in clinical trials

To date around 5000 patients have been entered in double blind clinical trials, and the efficacy in chronic pain and inflammation of this natural compound is clearly documented (1-5). This makes PEA one of the best documented effective and safe nutraceuticals. Sadly enough pain physicians do not often read literature on supplements, and seem to believe that only pharmaceuticals can be effective (but not so safe).

At the 8th European congress on Pain (EFIC) in Florence (2013) palmitoylethanolamide was presented in one of the main symposia as a new kid on the block, we hope this will help opening the eyes of doctors that patients can be helped also with natural compounds, without side effects….

PEA has been used by more than 1 million patients, mostly in Europe. In the Netherlands and Germany since the beginning of 2011 many ten thousands of patients are using it. Mostly to their satisfaction. Meanwhile many other patients elsewhere, especially at the west coast of the USA, in Australia and Canada, are using PeaPure.

First a scientific introduction on the mechanism of action of PEA related to the cause of chronic pain in a Youtube presentation.

Here a PREZI with the essentials of PEA.

A new natural painkiller, palmitoylethanolamide (PEA) is available under the brandname PeaPure, produced in the Netherlands and available via the webshop from the distributor.  In Italy PEA is available at pharmacists under different brandnames, such as PeaVera, Normast, PeaLut, Glialia, Adolene and Pelvilen.  These products all contain PEA, but in different amounts (see below).

Information for prescribing doctors and for pharmacists related to PEA you find under this link.

While the certain products containing PEA belong to a specific category, food for medical purposes (such as Normast and PeaVera), and can be obtained only in countries were such categorization has taken place (e.g. Spain, Italy); other PEA products are classified as supplements (PaePure) and freely available. Here the list of all PEA containing products and their classification:

PeaPure: 100% pure PEA, supplement
PraVera:100% pure PEA, Diet-food for medical purposes (Italy)
Normast: 68% pure PEA, Diet-food for medical purposes (Italy, Span)
Visimast: 68% pure PEA, Diet-food for medical purposes (Italy)
Pelvilen: 50% pure PEA, Diet-food for medical purposes (Italy)
Adolene: 50% pure PEA, Diet-food for medical purposes (Italy)
Glialia: <50% pure PEA, Diet-food for medical purposes (Italy)
Achilles: <10% pure PEA, supplement

The classification food for medical purposes is only valid in Italy and Spain.

There are no clinical data supporting one product over an other product, the efficacy is comparable and the different formulations seem only to have its use in the context of formulation patents. In countries were PEA is not classified as food for medical purposes, only the supplement can be ordered.

Recently, based on various scientific facts, R. Kriek argued to make the choice for pure PEA, as in PeaPure and PeaVera (Kriek, 2014):

Based on additional studies discussed in this commentary and in view of the effects of ultra-micronization on the parameters discussed, as well as the potential side-effects of additives such as excipients and herbal extracts added to the products cited in the article, the preference should be for the time being to treat patients with pure PEA without any of these additives.

PEA and the scientific support for its use

PEA has been evaluated in a great number of scientific papers, more than 400! PEA is sometimes referred to as an ‘autocoid’. An autocoid is special modulating molecule, produced by our own tissue, and able to modify our own biological balance. PEA has been found useful in a variety of chronic diseases, amongst others in severe neuropathic pain, sciatic pain, prostate pain, pain after stroke and in MS and pelvic pain. Side effects are neglectable, due to the fact that this molecule is part of our own body. It has special analgesic properties, and in sciatic pain for instance, it is much more effective compared to the chemical analgesic Lyrica (pregabaline)!

PEA has been demonstrated in recent trials to decrease pain in diabetic neuropathic pain, zoster pain lumbosacral pain (sciatic pain), carpal tunnel syndrome and nervus medianus compression pain, endometriosis pains, menstrual pains, etc. It has been proven to be effective and safe in many different disorders, from chronic pains up to flu and common cold, due to its intrinsic anti-inflammatory and analgesic properties. Now PEA can also be considered as a breakthrough natural therapy for flu and common colds.

How to use Pea?

PeaPure as a supplement comes in capsules of 400 mg, containing finely powdered (micronized) pure PEA, no pharmaceutical additives or fillers or any artificial additive.

You can start taking three 4 400 mg capsules a day, in 2 or 3 gifts. The dose can be increased up to 2400 mg daily. Mostly we advise patients to double the  dose only after 4 weeks, and only in case of issuficient efficaccy.

If pain improves after some weeks to 2 months one might want to decrease dose to 2 times 400 mg.

If no improvement after 2-3 months, stop. Painkillers such as PEA, but also Neurontin, Lyrica and Amitriptyline (brand name Elavil all need time to reset the system, mostly 1-2 months.

Always inform your physician just to keep him/her in the loop.

For physicians and pharmacists all relevant information can be found via the links to peer reviewed journals in:

1. Keppel Hesselink, J.M. 2012. New Targets in Pain, Non-Neuronal Cells, and the Role of Palmitoylethanolamide. Open Pain Journal 5: 12-23

2. Keppel Hesselink, J.M., Hekker, T.A. 2012. Therapeutic utility of palmitoylethanolamide in the treatment of neuropathic pain associated with various pathological conditions: a case series Journal of Pain Research 5:437 – 442

3. Keppel Hesselink JM, Kopsky DJ, Treatment of chronic regional pain syndrome type 1 with palmitoylethanolamide and topical ketamine cream: modulation of nonneuronal cells. Journal of Pain Research 2013

4. Keppel Hesselink, J M,  Tineke de Boer, and Renger F. Witkamp. Review Article. Palmitoylethanolamide: A Natural Body-Own Anti-Inflammatory Agent, Effective and Safe against Influenza and Common ColdInternational Journal of Inflammation Volume 2013 (2013), Article ID 151028, 8 pages

5. Keppel Hesselink JM. Chronic idiopathic axonal neuropathy and pain, treated with the endogenous lipid mediator palmitoylethanolamide: a case collection. International Medical Case Reports Journal Published Date September 2013 Volume 2013:6 Pages 49 – 53

Further references

Kriek R. Palmitoylethanolamide: problems regarding micronization, ultra-micronization and additives. Inflammopharmacology. 2014 Mar 20. PMID: 24647619

Kriek R. Marketing messages in pharmacological papers and scientific chapters: The case of palmitoylethanolamide and its formulations. Pharmacol Res. 2014 Apr 24. pii: S1043-6618(14)00047-4. doi: 10.1016/j.phrs.2014.04.007.

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209 responses

  1. I am a gynecologist in NYC with a specialty in chronic neuropathic pelvic pain and would like to know where I can order normast for my patients– thank you, Deborah Coady MD

  2. Normast can not be ordered, as it is a special Italian food for medical purposes drug, available via Italian pharmacists. PeaPure is a supplement containing PEA easiy to be ordered via the internet

    1. palmitoylethanolamide4pain | Reply

      Normast cannot be ordered anymore as indicated above; PeaPure, also containing palmitoylethanolamide can be ordered via

    2. hi , i am Avinash from India. i am diagnosed with syrinx in spinal cord at cervical region. I am in tremendous neck pain and neurosurgons have asked me to go for surgary. i seen few of similar surgeries on youtube and quite afraid off .
      read somewhere about Palmitoylethanolamide for treating similar reasons. can anybody in world will enlight me about the effectiveness of Palmitoylethanolamide on syrinx and where will i get it from? i need it urgently and desperately .pls reply and help me .god bless you. i am not sure when i will come back to this site again.

      1. palmitoylethanolamide4pain

        you can definitely try it and it is easy to find on But probably you need double dose!

  3. My mother suffered from severe pain in the hips and legs and I ordered Normast and started with 600 mg twice daily, after 1 week the pain decreased and now, 4 weeks on Normast my mother is a different person. I am a nurse and this painkiller is really a major step forward, I never thought a natural compound could be so effective!

    1. Dear Peter,
      thanks for sharing this with us. We see the same effects in many of our chronic pain patients and are very happy for them. PEA can also easily be combined with other painkillers, and sometimes even reduces side effects of compounds such as pregabalin!

  4. Carl Mac Donell | Reply

    Are there any difficulties receiving the shipments in the US or Canada – ?FDA Regulations?

    1. The organisation Ergomax ships Normast as a supplement to Canada and USA without difficulties, they know how to handle the shipment issues.

      1. palmitoylethanolamide4pain

        Meanwhile, since 2012 the organization JP Russell Science ships to the USA and Canada, and up to now many buyers have received shipments without problems.

  5. Francis Hussey MD | Reply

    Thinking of trying a patient with Thalamic pain/post lacunar infarct on Normast. Is there any published reports on using this on other Thalamic Pain patients?

    1. This is one of my patients:
      Dear Francis,

      This is a report of a patient of minde suffering from central neuropathic pain:

      I am so busy that I do not find the rest to write more case reports for literature, but Normast in my hands is quite impressive. Last weeks I also got feedback from a vet neurologist, that central neuropathic pain in dogs is also responding to Normast.

      Please start on sachets twice daily 600 mg, perhaps even 3 times, and do not lower the dose under 600 mg twice daily. You can add Normast to any analgesic and pregabaline is a good one to add in on.

      Let me know your findings if you start prescribing Normast.

      Best regards!

  6. This is a patient suffering from artrosis pain and angina pectoris pain:

  7. Can you tell me how this is metabolized, and what the half life is? Also for people in pain management programs, will they need to disclose the use of this medication? Will it be evident in their regular urinalysis?

    1. Dear Laura, as palmitoylethanolamide is a compound our own cells produce, it is easily metabolized via an intracellular enzyme called FAAH. Its metabolism does not effect renal or hepatic systems, as it takes place in all cells. So it will also NOT popp up in urine, neither in faeces, and the easy thing is you can combine it with whatever medication, without fear for interactions.

  8. Hi, is there any monograph of this drug? and, is it available in México?

  9. Is this product useful to treatment of neuropathy due to chemotherapy with a platin compound? If positive answer, please clarify if only for pain or also to eliminate the neuropathy. Thanks a lot in advance.

    1. yes, palmitoylethanolamide has a very specific mechanism of action, read the science around the molecule, for instance on, or on it is as well a compound that inhibits pain, inhibits inflammation as well as a neurorestaurative compound…

  10. Are you able to get Normast in South Africa?

    1. Via PEA as a supplement can be shipped without problems to any place in the world.

  11. I suffer from neuropatic pain after a stroke last year. My doctor spoke with me about normast and I ordered the sachets and the 600mg tablets. My doctor told me to take the sachets for 10days and then 40 days the 600mg tablets. After trhe 600mg tablets if I got relief I should take the 300mg tablets. I asked my doctor how long I should take the 300mg tablets but he could not give me an answer. Do you know how long I should take the 300mg tablets? Regards Jose

    1. If suffering from neuropathic pain after stroke, keep using Normast twice daily ate least 300 mg…after 6 months try one tablet…after 6 months try stoppping. In case of increase of pain start twice the 600 mg sachets for 20 days before going to tablets again…

      1. I am taking Normast (sachets) since 5 days together with Lyrica and the only reaction that I noticed till now is that I am getting less side effects from Lyrica (somnolence,dizziness,rush). Is this a normal reaction

  12. Dr. thomas Mueller | Reply

    Mein Neurolog diagnostizierte im Juli dieses Jahres bei mir ein neuropatisches Schmerzsyndrom nach einem Schlaganfall. Wegen eines brennendes Gefuehls im Ruecken konnte ich nicht schlafen und bekam Lyrica 150mg am Abend. Der Neurolog sagte mir diese Woche ich koennte vielleicht Lyrica reduzieren wenn ich Normast einnehme (Lyrica vertrage ich nicht gut wegen der Nebenwirkungen). Er wusste aber nicht ob es Wechselwirkungen zwischen Lyrica und Normast gibt. Er hat mir empholen Normast 600mg sachets fuer 10 Tage zu nehmen danach 600mg fuer 6 Woichen. Nach der ersten zwei Wochen falls das brennende Gefuehl weniger wird soll ich Lyrica um 25mg woechentlich reduzieren. Vertragen sich Lyrica und Normast gut oder soll ich auf etwas aufpassen?

    1. Normast can be used without difficulty together with LYrica and indeed reduces side effects and enhances the analgesic effects! Taper out Lyrica when pain is significantly less due to Normast, slowly, slowly!

  13. this is a very interesting treatment for chronic inflammatory pain. this may be the answer that many of us have been looking for. are there or have there been any recent studies being done in the US, either now or scheduled in the near future?

    1. all studies have been done in Europe and on wiki i put al the science as well as on:
      this link is for doctors to review all science!

  14. is there any indication of a US carrier/ supplier in the works?

    1. all is shipped to USA via and comes in the USA in good order…

      1. Mine has not shipped in good order. It has been held in St. Louis waiting for inspection by the FDA for 4 days now, with no sign of when, or if, it will be delivered. $300.00 down the drain?

      2. i heard it was solved!

      3. palmitoylethanolamide4pain

        Since 2012 the shipment of PeaPure (in stead of Normast, containing the same PEA) is via the organisation Russell Science,

  15. Are there any studies that indicate a blood lipid/glucose lowering effect of palmitoylethanolamide, as has been shown for another PPAR alpha-activating nutraceutical, pterostilbene?

    1. No effect whatsoever on blood glucose, neither on lipids as far as I am aware off. I’ll ask around too.

  16. Does Normast help with CRPS (Complex Regional Pain Syndrome) Pain?

    1. In our clinic we developed a new treatment protocol for pains in CRPS, Sudeck’s dystrophic pains. We combine various treatments, all with a low propensity for side-effects. Basically our treatment protocol consists of:

      1. Topical analgesic creams:

      a. start with ketamine 10% racemic cream and on top of it (if necessary) DMSO 50% cream.

      b. or switch to amitriptyline 10% cream ( with/without DMSP 50%)

      c. switch to Algonerv cream on top of either one of the creams before (consisting of the immune-modulator adelmidrol and capsaicine low concentration)

      Creams in addition to:

      2. Normast (palmitoylethanolamide) 600 mg twice daily.

      Start with 20-30 days on Normast powder sublingually (melt in saliva under tongue, not to swallow, but to resorp in the mounth, and after treat with Normast 600 mg tablets twice daily. (order by

  17. Thank you for your reply. I have done a lot of research into CRPS and treatments and I am unable to get Ketamine Cream here in the U.K. but I will ask my doctor about Amitriptyline cream. I have already spoken to the clinic ( who say they can send Ketamine Cream to U.K. if my doctor writes to them, but she is not willing to do this. I have already ordered (yesterday) Normast Sachets and tablets, R + lipoic acid and Algonerv cream from ergomax, but I only ordered 10 days worth of sachets – so you think 20-30 days would be more beneficial to me rather than 10? If so, I will order more. Also, should I take the lipoic acid or not and if so, how often? Thank you for all your help, it is much appreciated. With regards, Karen

    1. I am unable to get Ketamine cream or Amitriptyline cream in the U.K. I am using Algonerve cream and Normast Sachets. Any ideas on how I might get Ketamine cream?
      Thank you

  18. yourn physician can ask for a special delivery from Holland of 10% ketamine cream via

  19. I have already asked my docotor if she will do this for me but she will not. I think it is because she (and other doctors) here in the U.K. do not know about Ketamine Cream. I wonder if anyone else in the U.K. has managed to get hold of Ketamine Cream?

    1. ketamine tablets are also useful for neuropathic pain. Can use 20-30mg up to 4 times a day. We can get these in US very easily. Also relieve depression, that is a nice bonus. AEmeryMD

  20. Has Normast been used for chronic bladder inflammation (Interstitial Cystitis)? I have tried and failed several treatments, including bladder instillations and oral medications, either due to intolerable side effects, or worsening of pain in the case of instillations. I live in the U.S. Thank you!

  21. Can you drink alcohol (wine) with Normast or does it affect the way Normast works?

  22. Please let me know if Normast could help with severe, chronic muscle spasm cause after a stroke. The intractable pain does not respond to opaites, muscle relaxants or Lyrica.
    Any advice would be appreciated.

    1. you can always try it out, no problems with drug-drug interactions, start on powder from PeaPure 400 mg 3 times daily for under the tongue:

      In our practice we prescibe palmitoylethanolamide for a great variety of neuropathic painstates, mostly with impressive results. Combination of therapy with opiods, gabapentoids and antidepressants is possible, and no drug-drug interactions have been reported.

      The dose to begin with is always 1200 mg palmitoylethnalamide/day.

      In case of partial response, higher doses are possible up to twice daily 1200 mg.

      In case of a relapse under tablet regime, transfer patients to 600 mg Normast sachets for at least 20 days. Some patients, especially those with central neuropathic pain sometimes respond on sachets, but relapse on tablets.

    2. The difference is that sachets are absorbed sublingually and the tablets are swallowed?

      1. palmitoylethanolamide4pain

        You can do all, swallow or put under the tongue…in the clinic it seems not too matter, unless your are a migraine sufferer, than sublingual seems to have more of a direct effect…

  23. Anastasia Lusas | Reply

    Have you had patients with Vulvodynia try this? Thanks!

    1. Yes: Palmitoylethanolamide is available for clinical use and is widely available via the webshop of the organisation Russell Science Ltd, who distribute a GMP certified, pure PEA capsule as PeaPure. Palmitoylethanolamide is also available in Italy and Spain via the pharmacists.

  24. Thank you for your reply. I’m not sure what to start out with, Normast (sachets for 10 days, 600 mg pills for 40) or Pelvilen Forte and Saginil? My Vulvodynia includes pelvic and pudendal nerve pain, especially in the sits bones and glutes. I’m trying to stay away from putting gels/creams in the vaginal area as a lot burns it right now due to lots of use of other cream medicines.
    Should I start out with the regular Normast and just go from there? I want to make sure I get the best formula for my situation.

  25. What are Pelvilen Forte and Saginil? How do we obtain them (and Normast) in the U.S.?

  26. Anastasia Lusas | Reply

    Diana: They need to be shipped in from Europe via Ergomax, check up above. You can’t purchase them in the US unfortunately.

    Pelvilen Forte and Saginil are more specifically for those with Vulvodynia and Chronic Pelvic Pain

  27. Normast- Do I need to take the noramast sachets to start pelvilen forte or can I just start with the peevilen forte? Thanks!

    1. best always start with 10 days sachets twice daily under the tongue

  28. angelica ampuero | Reply

    I have a question related to normast interaction with zopiclon, valeriana and withania somnifera.
    I got pain (middle pain) in the back after a stroke. Due to the pain I have problems to sleep.
    I take zopiclon (3,75mg), valeriana (300mg) and withania somnifera (1,5 ml of 2:1 tincture)
    Can I take normast without problems or are interaction to the above mentioned products

    Angelica from Germany

    1. Yes, there are no interactions known or described!

      1. I have been taking this drug for 7weeks and found i have a lump that has come up near my shoulder blade

      2. during whatever therapy things may happen, related or unreleated, in case of doubt always stop. PEA however is known for its anti-tumor effects…

      3. Dear Trish, I am not a physician; however, anytime you find a lump, you need to seek medical advice immediately. PEA is NOT a drug per se, but a naturally occurring substance. . It is a supplement. It can do a wonderful job of easing nerve pain in cells like nothing else I have found. It does not make cells grow into a “lump”. Although it took over 2 months to work for me, it’s pain relieving properties work like nothing else available on the market. Hope your healing continues and that you seek attention soon for your concerns. Best to you and your body wisdom in your healing adventure.

      4. totally agree!!!

  29. nicholas brooks | Reply

    I would like to know more I live in usa

  30. nicholas brooks | Reply

    I live in hammond LA. I have Ms and have found no ressonable method for easing the pain I have daily. I am on provigil for my lack of energy. Could this help with my pain!

  31. Normast can be used alover the world, because ships it as supplements for personal use to the USA and elsewhere without problems, also to Germany

  32. I’ve tried everything for my migraines would this work for me

    1. try the Normast powder under the tongue directly before a migraine attack…

  33. Jeremie Gregory | Reply

    I’ve had sciatica in the lower back down my left buttock and into the leg to my toes. It has drastricly changed my outlook on life.

    1. Johan van Lamoen | Reply

      Dear Mr. Gregory,
      The description of your symptoms fits perfectly well the ones I am suffering from. Before the neurologist starts with nasty traditional medicines, I would prefer to use Normast or PeaPure without delay.
      I would be grateful, if you could be so kind to tell me your experiences with these supplements.
      Many thanks and kind regards,
      Johan van Lamoen
      Pristhina, Kosovo

  34. Jeremie Gregory | Reply

    Could I have info about ordering normast in english?

    1. you can find all info in english on and order it from there

      1. palmitoylethanolamide4pain

        Ergomax does not deliver anymore

  35. Hello ,
    for syndrome myo fascial and pudendal nerve
    what’s better pelvilen forte 400mg +40 or Normast 600MG for begin and continue?

    is those items items relaxes muscles?
    or it is there a natural supplement to relax the muscles of the buttocks?


    best regards

  36. Hello I’ve forgot :

    for irritated skin and very dry skin due to LYRICA ,is Normast or pelvilen Forte has an action? or it is there a natural supplement ?

    best regards

    1. palmitoylethanolamide4pain | Reply

      Just take PEA, 1200 mg/day up to 1800 mg

  37. Finally a solution!!!
    I am 99% pain free using Normast 600 mg and Sachets for my chronic pain, see here a really informative website and testimonials

    1. palmitoylethanolamide4pain | Reply

      The site painkillernormast does not exist anymore, so do not bother looking for it. Most scientific information related to PEA is collected on this website, which by the way, is not linked to any commercial organisation.

  38. palmitoylethanolamide4pain | Reply

    From 5th November onwards PEA can be ordered via the organization as PeaPure. It is advised to start with 6 packages of 30 capsules of 400 mg, and take 1200 mg/daily

  39. Hello
    I suffer from peripheral neuropathy( burning, cold, scale 7 from 10) in my left hand and half of my head and left leg after an apoplex. Should I take 1200mg PEA or 1800mg and can I combine normast with peapure.

    Luis Moran

    1. palmitoylethanolamide4pain | Reply

      You can combine Normast and PeaPure, as both contain palmitoylethanolamide. You should start with 6-8 weeks on 1200 mg PEA (either as Normast 600 mg or as PeaPure 400 mg). If pain is not less, you can try increasing the dose. Increase with 2 times 400 mg. If no pain reduction after 2 month, stop; in case of good pain reduction look whether 400 mg PeaPure twice a day or one tablet Normast does the job too. Good luck!

  40. Hi

    The ergomax supplier of Normast is not coming up on the google search. I have tried clicking on the links provided and the message I am getting is that the server could not have been found. Can someone please help on how to order these for vulval pain.


    1. palmitoylethanolamide4pain | Reply and you can find palmitoylethanolamide in PeaPure

    2. palmitoylethanolamide4pain | Reply

      Ergomax stopped in 2012 and PeaPure is introduced in NL and abroad.

  41. Does Peapure pass US customs without any problems? I was ordering and using Normast and did not encounter any customs problems. What about Peapure?

    1. palmitoylethanolamide4pain | Reply

      we heard it is the same procedure and has been shipped already to USA and Canada

  42. palmitoylethanolamide4pain | Reply

    We keep getting questions: were can we buy, were can we purchase PEA. And if we buy PEA and we are living in …USA, Canada, Australia, etc does it arrive. PeaPure can be purchased via the webshop of and according to the company Russell Science Ltd, the producer of PeaPure, they sent PeaPure within one day to all countries in the world, without difficulties.

  43. Hi

    I have been suffering long term vulval pain with vestibulitis, only on the outside not internal pain, and would like to order peapure and Saginil. Can you please advise if that is the best combination to address this type of pain, or do I need only Saginil for this type of pain? Could you also pls recommend the right dosages and how long should I take it for? Also, where can we order Saginil from? I now know where to order peapure.

    thank you

    1. palmitoylethanolamide4pain | Reply

      You can try first with the Pure Pea in PEaPure, if after 2 months not enough effects, you might want to ask your doctor about local amitriptyline 5% creme, it can be compounded by any pharmacists and most patients have good results by this cream. In the Netherlands Saginil cream is not sold anymore, as far as we know.

      1. Can you please advise the dosage I when taking peapure? Also, I was told that the manufacturer of Saginial now ships Saginil to different contries but only within Europe. They do not ship to Australia, or America. Would you recommend Saginil over amitriptyline if I can get a hold of it? On vulval pain forums amitriptyline cream is not that much recommended partly because many do not know about it and partly because it has not yielded great results. I am currently takin nortriptyline by mouth and it’s ok as it takes the edge of the pain. I would rather try something more natural and possibly more effective like Saginil.


  44. Hello,
    I have taking normast 300 2 days ago. Can it be produce diarrhea?? Thanks.

    1. palmitoylethanolamide4pain | Reply

      In Normast there are some excipients which are not 100% natural, but it is quite unknown whether these would lead to diarrhea. The Sorbitol in Normast 600 can produce diarrhea. For the time being I would suggest there are probably different causes for diarrhea.

  45. Hola, he estado hoy al medido porque llevo unos meses q se me duermen los brazos y me dan calambres y se me duermen sobre todo por la noche y me despiertan del dolor. Me ha mandado Normast pero no me ha especificado si de 300gr o 600gr como he estado leyendo que hay, me ha dicho q tome 1 mes 2 comprimidos al dia y 2 meses despues 1 comprimido al dia, entonces no se cual sera el que tengo que tomar. Tambien queria preguntar si este tratamiento se puede dar a gente que tiene problemas de artrtitis y artrosis y si hay buen resultado. gracias

    1. palmitoylethanolamide4pain | Reply

      Recomendamos especialmente PeaPure 400 mg. Debido a que hay cargas químicas en PeaPure. Con Normast también trabajamos. Ambos productos contienen PEA y se pueden tomar. PEA puede reducir el dolor y reducir la inflamación. Hay buenos resultados en la osteoartritis y la artritis. Dosificación al menos 1200 mg por día. Y un máximo de 30 mg por kg de peso corporal.

  46. I have been suffering with Idiopathic Peripheral Neuropathy for 3 years or more and have been prescribed Lyrica. Does anyone know if the Normast or Peapure would work for me and if so the prescribes amounts.

    1. palmitoylethanolamide4pain | Reply

      The first weeks start with 3 times 400 mg PEA, either given three times daily, or in the morning 2 capsules and 1 capsule in the evening. After some weeks, in the case of insufficient effects, one should (could) increase the dose to two capsules three times daily (or two times daily). Response mostly occurs in the first 1-2 months.

      The first things to notice are a general feeling of increased comfort, and a decrease of the intense peaks of pain. In the following weeks responders note a less intense pain.

      PEA is very safe and even in children doses up to 50 mg per kg Bodyweight were tolerated without side effects. For adults the max dose tested was 100 mg/ kg Bodyweight.

      If after 2 months not sufficient results have been seen, one can either increase further (up to 30 mg PEA/ kg bodyweight) or try a week 3 times daily the content of a capsule under the tongue. Let it melt. The resorption via the oral mucosa might give an extra impulse in non-responders. As said, PEA can be combined with any kind of other medicine.

      1. Hi, I have just been re reading your response below and was wondering if it can be taking with Lyrica which i have been prescribed for the last 3 years as I know I will not be able to come straight off them because of the pain

        Thanks Sarah

        Sent from my iPad


      2. palmitoylethanolamide4pain

        There are no known negative interactions between PEA and other compounds

  47. Hi
    I take a blood thinner medication, so I can not take anything that would cause internal bleeding like an stomach ulcer. Can this cause stomach ulcers or any internal bleeding? Thank you for your help.

    1. palmitoylethanolamide4pain | Reply

      No it is a body own lipid molecule, no influence on blood coagulation

  48. Is there anywhere that I can get this in the Uk? Please

  49. I began to treat my dad last year with Normast sublingual twice a day, after he was diagnosed SDAT and Base Nuclei stroke. Surprinsingly his movements and memory and language went better and better already after 2 days of treatment. Thanks

    1. palmitoylethanolamide4pain | Reply

      PEA is indeed sometimes quite supportive for SDAT! Because PEA inhibits the neuroinflammation around the plaques and tangles in the brain.

  50. Thanks, I’ll try and give y a response

  51. Hi,
    I suffer from Endometriosis (stage 4), Sciatic Endometriosis, Fibromyalgia, Sacroiliitis, a tumor inside my spine (S1), CTS, Anal Sphincter damage, Chronic Pelvic Pains, Meralgia Paresthetica, Levator Ani Syndrome, HLA B27 positive, B12+Ferritin deficiency, HPV=CIN II-III, OHSS… Have I forgotten something?!… I’m 42 years old, i’m vegetarian. I am, at the moment, on Visabelle, Lyrica & Cannabis and will shortly going off Visabelle&Lyrica.
    I would be grateful if you could recommend to me which of your pills would suit my condition best, what the recommended dosage for my health problems would be & how am I able to purchase the product. I live in Israel, but if it would make things easier & faster, I can arrange purchase & delivery from Italy or Rumania.
    Thank you very much,

    1. palmitoylethanolamide4pain | Reply

      Dear Slomit, you can try PEA, especially the capsules of PeaPur are garanteed 100% vegetarian, I would like to suggest taking 1200 mg/daily for 1 month and if the pain has not decreased sufficiently increase the dose to double (e.g. 3 times 2 capsules). Other PEA formulations contain different excipients, and sometimes the filler magnesium stearate is from animal sources. PeaPure is a foodsupplement and can be shipped all over the world. Good luck!

  52. […] In the following sequence of presentations we bring to you the essence of knowledge around the body-own compound and supplement palmitoylethanolamide! We start with the general introduction, an overview of palmitoylethanolamide, an endogenous cellular protectant in plants, invertebrates, vertebrates and humans, tested extensively since 1970 and widely available as food supplement. Its main action is analgesia ( a natural painkiller) and inhibition of chronic inflammation. More can be found under this link (what it is, how to use it). […]

  53. Good Morning. Is it possible to get some studies where palmitoylethanolamide was used in patients with chronic pelvic pain?

    I will appreciate that!

    Whay about of product representation in Latin America (Colombia). Where could I get?


    Giovanni Riaño

    1. palmitoylethanolamide4pain | Reply

      There is a lot on pelvic pain and palmitoylethanolamide, just google will take you there; PeaPure is easy to get in the internet and easy to ship to your country.

  54. Howdy. data will be for extra soon.
    I know this website information

  55. I have IC and chronic pelvic pain.
    I have been taking Normast and Pelvilen for two years with scarse results. Do you think it is worth I start use PEA ? I don’t have twitter, could you reply to my email account?

    1. palmitoylethanolamide4pain | Reply

      if you took sufficient dose and no response in 4 months drop it, you are a non responder sadly enough

  56. le pea pure est-il conseille pour une personne atteinte du SLA qui souffre de douleurs intenses . le SLA a été diagnostiqué il y a 2 ans actuellement la patiente est entièrement paralysée, elle à des difficultés respiratoire et de déglutition.
    Merci pour votre conseil; si ce médicament convient, me dire la posologie et la bonne indication commerciale de ce médicament. Je peux le faire venir d’Italie- d’Espagne , de Suisse ou éventuellement du Canada

    1. palmitoylethanolamide4pain | Reply

      vous pouvez essaier du PeaPure et de double posologie: le premier semaine 3 fois 400 mg, et apres se semaine double dose. Ou vous pouvez essayer Normast 2 fois 600 mg et le meme double dose apres 1 semaine

  57. […] but you might have to eat quite a lot of it. The alternative is a pill. There is quite a choice:- If you want to buy in bulk you get a discount:-   […]

  58. I am all for natural products and am a naturopath myself. But….I was recently given Pelvilen Forte by a doctor who had prescribed the pain killer to me to take in the evening, obviously ignoring the pain i was experiencing. I livein Milano, Italy and spent 2 days in the hospital with what I thought was kidney stones however all tests came back negative yet I have inflammation and I can’t walk for the pain. They discovers a minor bacteria infection in my bladder and have decided to treat that wi th antibiotocs and Pelvilen Forte. I can assure you the Pelvilen does not work. I am in excruciating pain and had to supplement it with ibuprofen. Perhaps because it is only 50% active and perhaps because I juat started. I’m keeping my fingers crossed but if a patient continues to tell you she can’t walk and there’s pain, and the doctors continue to say you have nothing. .I don’t know who’d I believe? …obviously the patient! !! I’m an athlete, practiced martisl arts so to be cowering in pain is abnormal amd means my body has something that isn’t right. .btw…ibuprofen immediately kicked in. ..thabk god I feel thebpain subsiding after 3 hours of waiting for the pelvilen to kick in.. I still hope for the best with this product but I’m not happy right now as I’m so uncomfortable that.. this is my response to its “immediate effect.”

    1. palmitoylethanolamide4pain | Reply

      Not in all patients PEA works directly, most need to be treated for weeks (as is the case with Lyrica etc), and of course some respond very good and there are always patients which are non-responders. Therefore, if no results after doubling the dose of PEA for some weeks, then stopping is the only option.

  59. I started peapure 3 times a day for another inflammatory problem, but I discovered first dose improvement in my irritable bowel symptoms. Less rumbling and uncomfortable sensations. Nice surprise! But my real problem is early symptoms of arachnoiditis due to three epidural blood patches and 2 lumbar punctures. Have any patients with arachnoiditis noted improvements in pain or nerve symptoms like twitching?

  60. I recently tried one days worth (1200mg) of pea pure, taken in three doses. I have m.e/CFS though I do not experience many pain symptoms. The pea pure caused me to become incredibly sleepy and fatigued, also giving me bad pain in my lower legs. I still have these symptoms two days later. What is going on? I’ve had a similar reaction to other anti inflammatory medications and would love to know what is happening with my system. Is it possibly effecting my dopamine somehow? Please let me know if you have any answers, cannot find anything online about it.

    1. palmitoylethanolamide4pain | Reply

      sometimes people act like different, always go slow and start low in those cases….one thinks all the bad shit is coming out to create a new more healthy balance….

  61. I quickly received 6 boxes of PeaPure from the Russell labs in Cyprus (?). (I thought the company was in the Netherlands). Just started a few days ago, so will post results in a few weeks. Am trying this to help with atypical facial pain, migraine, sciatica, neck pain, and chronic regional peripheral neuropathy.

    I do have diarrhea since starting but that will hopefully resolve. I just switched to putting powder from the capsules under the tongue.

    It would be nice if the PeaPure site had a currency converter on the order page so you know what you’re paying in U.S. dollars. If this supp. works, I’m going to have to get a job to afford this stuff! (Just retired and on a very tight budget). Any U.S. companies coming up weigh a pure form, or does J.Russell have a patent? Also, in doing research on this, all the papers seem to refer back to one person, a Dr. Hesselink. He is apparently the PEA authority. Does anyone know if he has a connection to PeaPure?
    In Southern California

  62. Can you tell me how to order PeaPure or Normast? I live in Atlanta, Ga , USA, and cannot seem to find any way to order these products online? If I can order them, is the product itself and the shipping very expensive? Thank you very much.
    Best regards.

    1. palmitoylethanolamide4pain | Reply

      You can find all answers on the site of the shipping company! But indeed online is the way…

  63. I ordered from
    This is the JS Russell co. that makes PeaPure, with offices in Cyprus. They ship directly to the U.S. The package came in less than a week with the correct contents and order sheet. If the link doesn’t work just Google . Good luck,

  64. In regard to US residents ordering PeaPure online, I have spent most of this year working out a reliable system of delivery for US residents. We are doing this on a patient-to-patient basis. (It is not a big faceless commercial operation.)

    I founded a glaucoma community in 2006 and we use PeaPure for supporting healthy intraocular pressure levels as well as for potentially preventing neurodegradation. Many of us needed a reliable way to obtain a consistent supply of PeaPure, which is why I worked so hard on solving the delivery problems all of us in the US have faced this year (2014).

    So far we have focused on making PeaPure available just to members of our glaucoma community. However, recently we have started accepting online orders from others. (But we are still ramping up our ability to supply more people, so we are not widely advertising the available of PeaPure through our site. And we only deliver to patients who are using it for themselves.)

    My own experience, and the experience of most of the people I speak with, is that ordering from the manufacturer in Holland is NOT a good option for US residents.

    I did not receive a single one of my last six orders directly from rs4supplements. Many people I speak with tell me the same thing. And getting refunds is not easy. Even getting a timely email response from them is not easy.

    I know that there are some success stories ordering directly from the manufacturer, but overall far less than 50% of the shipments appear to be delivered to US residents without problems. And that success rate has gone way down this year. Comments from prior to July 2014 do not reflect the current status.

    In contrast our method has a 100% successful delivery rate.

    We usually ship PeaPure to US residents on Wednesdays each week. I tell people to expect a shipping time of about two weeks. Delivery is from the UK.

    Our price is almost exactly the same as ordering from the manufacturer (although currency exchange rates may cause the price difference to fluctuate slightly). When ordering from the manufacturer, your order will be shipped via FedEx. You will pay about $200 for 180 capsules at the time you order. In addition FedEx will send you a bill for $20 for customs brokerage fees. This invoice may arrive several weeks after your PeaPure (assuming your PeaPure arrives at all). The unfortunate thing is that you will still be billed $20 by FedEx even if you do not receive your PeaPure!

    In contrast, our price is $220 and includes all shipping costs and other fees. So the total price is the same. The difference is that delivery is more reliable. On average, our delivery time is also quicker although that may not be apparent unless you look at average delivery times across many orders.

    BTW, we have to pay extra taxes, shipping and other fees to effect our delivery process. So matching the manufacturer’s total price has not been an easy feat to achieve without losing money. However, we have a worldwide network of long time community members and several of them are volunteering to help us provide this solution. As I said, this is a patient to patient venture. We are patients and we use PeaPure ourselves. Although I think we are the very best option for US residents ordering PeaPure, please recognize that we are patients just like you.

    The website link is

    Please let me know if you have questions or comments. Thanks.


    1. Thank you, David. I just placed my first order through your site. I guess that I might ask you also. What dosage would be best to take the PEA (for me, it’s for chronic pain)? Do you find that it is better absorbed without food? Is it better absorbed to open the capsule and dissolve under the tongue? I just don’t want to waste my money by taking it in a way that it doesn’t get absorbed properly. Do you think that I might know within a month if it is going to help? Thanks again.

      1. palmitoylethanolamide4pain

        Just start by taking 3 times 400 mg capsules after diner. No need to open capsules. After a month most people feel better, if not increase the dose to double.

  65. Sorry, the company in Cyprus is JP Russell Science Ltd. I assume “” is for rScience, or Russell Science, the name on the letterhead that came with my order. Btw, I’m not promoting this brand. It’s appears to be the only one out there right now that has NO additives, just pure PEA.

    FYI, when I sprinkle the powder under the tongue and let it dissolve, there’s no weird taste or aftertaste. It takes a couple of minutes to completely dissolve. This keeps it from going through the gut, thus absorbing faster.

    Hopefully we’ll see a U.S. distributor in the future and maybe a price drop?
    Thx, JC

  66. Forgot to reply about cost. Yes, it’s expensive (for me, anyway). I got the 6 boxes of 400mg capsules (“buy 5, get one free”) for 114 euros. If you take the recommended 3 capsules a day, this supply will get you through 2 months. I plan to take this batch, and if it’s not working in 2 mos., move on.

  67. Thank you so much, each and every person, who reached out to tell me how to order this product from the USA. My sincere gratitude to you all.

  68. I should particularly thank Jeanne C for your kindness in replying!
    In addition, has anyone used PEA for helpful treatment of Hashimotos hypothyroidism? Thank you very much.

  69. Can anyone tell me if taking the 400 mg capsules of PeaPure twice a day for chronic pain is an adequate dose? So many of the trials has used 600 mg 2-3 times a day or other protocols or even more PEA daily. I just ordered my first batch of 180 capsules, but am confused and unclear what dosing schedule to follow. Do you take it with or away from food? Some trials gave it with food. Other articles say to take it without food.
    Since it is expensive, I was hoping that to make the best use of this first order, to see if it really helps me, but I want to apply the best dosage instructions. Can anyone advise their best information that they have heard? Thank you very much!

    1. palmitoylethanolamide4pain | Reply

      simple: start with 3 times 400 mg after a meal. see what happens, if after 4 weeks result keep the dose, if not double the dose for the remainder of time

      1. I am fast approaching the 2 month mark of taking a PEA 400 mg capsule 3 x a day. I don’t seem to feel any better with my chronic pain (central sensitization).
        Should I now try upping the dosage to 2 capsules 3 times a day, or do you think I would be wasting my time (and money)?
        Also, opening up the capsules to try taking it under my tongue does not seem easy. I must be doing something wrong, as the only way that I can see opening the capsule is biting it in the middle with my teeth. Using a knife didn’t work, and using my fingers to open the capsule, I don’t see how to do it, as I don’t see a line on the capsule where the 2 sides are adjoining.. When I do bite into the capsule to open it, I lose some of the powder on the ground, and even the powder that I can get into my mouth, I have a hard time getting it under my tongue. Am I doing something wrong?
        Thanks very much for any advice.

      2. palmitoylethanolamide4pain

        yes, lot is wrong: 1. do not open the capsule, not necessary (old info says it is, but it is not), 2. yes indeed double dose for 1 more month and if no result stop. Otherwise taper off after good result to see whether you can be stable on normal dose…good luck!

  70. I took the recommended 400 mg capsules 3x daily. Opened cap and put powder under tongue (I have a sensitive gut). No results after 6weeks for any of my chronic pain issues, so will try upping. Good luck. JC

    1. palmitoylethanolamide4pain | Reply

      That is a good idea, and remember, for analgesics mostly 30-50% of patients do not respond, this is less for PEA, but still you might be a non-responder. Try to add Low Dose Naltrexone to your regime.

  71. Are there any success stories for using PEA for allergies? Based on mechanism and anti-inflammatory nature I could well imagine it being useful.

    1. palmitoylethanolamide4pain | Reply

      there are indeed quite a number, just google and you will find those stories!

  72. Hi

    I was hoping if you can assist me about Peapure capsul.

    I have diagnosed with Small Fibre Nerupathy and it is spreading all over my body as well as my face ( I have burning mouth as as well). I am taking Peapure capsule since 20 days ago( 3 x 400 mg, after breakfast, lunch, dinner). I am taking nortriptyline with dosage of 20mg every night at the same time which anytime I had it , makes my pain worst.

    At the moment, I am thinking if the peapure does not effect till 4 weeks as well as it should be , what dosage it is recommended to take ? Can I increase it to 4x 400mg?

    I have a Peapure Cream as well but haven’t started yet.

    Much appreciated if you share your thoughts and advice me.


    1. palmitoylethanolamide4pain | Reply

      yes, you can increase the dose till 3 times 2 capsules a day, or spread it over 4 times (in total 6 capsules), use the cream on the most annoying areas of your skin, good luck!

    2. palmitoylethanolamide4pain | Reply

      YES, you can increase the dose up to 3 tims 2 capsules without problems, and add PEA creme

  73. Annette Higgins | Reply

    Is it available in Australia? I have servere fibromyalgia and my pain specialist has recommended it.

    1. palmitoylethanolamide4pain | Reply

      it is available everywhere via the internet

  74. annette higgins | Reply

    How much does the drug palmitoylethide cost? How do I source it and Im in Australia.

  75. Annette Higgins | Reply

    What is the price and is it available in Australia. I get pain everyday and finding it really hard.

    1. palmitoylethanolamide4pain | Reply

      you can find all your answers on and indeed in Australia one can also get it (via the net)

    2. palmitoylethanolamide4pain | Reply

      look at the sales shop for shipment and costs…

  76. Barbara davies | Reply

    Where can I buy the tablets in the uk babs

  77. Annette Higgins | Reply

    where can I buy the tablets in Australia/UK?

  78. I have vulvodynia
    What do you recommencement for me Peapure or Pelvilen ?

    1. palmitoylethanolamide4pain | Reply

      You can try each one after one another, for instance 2 months pelvilen and 2 months PeaPure and decide for yourself! Both contain PEA, only Pelvilen has 200 mg PEA and PeaPure 400 mg in each dose (tablet or capsule).

  79. My mother, who has fibromyalgia, is very interested in getting started with PeaPure. She is scheduled for cervical surgery soon and has been advised to not take any anti-inflammatory meds after surgery because they inhibit the healing process. She is wondering does that apply to PeaPure as well? I know that PeaPure is designed to help aid the body’s natural healing process, so I assumed she would be fine to still take it, but I just wanted to double check! Thanks for any help :)!

    1. palmitoylethanolamide4pain | Reply

      PEA indeed can be used but do not nerve the surgeon and wait for 2 weeks after te operation before starting PeaPure…

  80. Annette Higgins | Reply

    General Enquiry – Where can I get it in Australia?

  81. Barbara and Annette:
    I’m not sure if my prior messages reached you (or anyone). I’ll be happy to help you obtain PeaPure if you wish. Click the link in my name (above this message) and contact me via the FitEyes website. Thanks.

  82. Annette Higgins | Reply

    I have contacted the FItEyes website.

    1. palmitoylethanolamide4pain | Reply


  83. […] when you have neuropathy. I don’t know how it works with other pains. Here is another link: I advice you to seek medical advice first. Not because of any dangerous side effects (but that is […]

  84. I have had vulvodynia for 15yrs with not a lot of relief from trycilc antidepressants.i am currently taking tapentadol &cymbalta for nerve pain &bladder pain caused by vulvodynia.could you tell me which product would be the best to try.After doing research some say use micronised PEA only& only Normast produces this.I am confused by this so don’t know which product to use.I live in the uk and I am having problems sourcing it,I also take levothyroxine along with the above medication would it be safe for me to try this supplement ,which one should I take and at what dosages.thankyou in advance Anne.

    1. palmitoylethanolamide4pain | Reply

      Both PeaPure and Normast are produced according to a patent, in such a way, that in the capsules PEApure and in the tablets Normast there are micronized and ultramicronized PEA particles. It would be safe 4 you to use either one.

  85. Hello. I just ordered PeaPure for my father. He had two massive strokes, one affected spot being the left thalamus. He is showing signs of Central Pain Syndrom (pressure, freezing, pain on his right side) so I thought we’d try getting him on PeaPure. I just ordered the capsules. At the moment he is on tube feeding. My question is: is it fine to dissolve the capsule in water and put it through his feeding tube? We predict he should be able to have things by mouth at some point, but he can’t right now. Thank you!

    1. palmitoylethanolamide4pain | Reply

      yes, you can mix it in any liquid for instance yoghurt or milk, good luck!

  86. […] PEA is a body-own fatty compound, and is produced by our own living cells to restore balance in chronic pain and chronic inflammation. Its anti-inflammatory and painkilling properties are known in science many decades since the first description of this compound in 1957. in 1993 the Nobel price winner professor Rita Levi-Montalcini pointed out the relevance of PEA for medicine and since then more than 300 scientific papers on PEA have been published. She also was the first person discovering the mechanism of action of PEA. (Ref) […]

  87. I have interstitial cystitis and everything my doctors tried – Elavil, Vistaril, gabapentin, bladder instillations made my pain worse. I ordered Pea Pure from R4S supplements and began taking 400 mg with water at breakfast and lunch. This is the first thing that gave me relief for my bladder pain. However, after 1 day, I began to experience severe abdominal pain and heartburn. I have read about Pea Pure having no side effects but this is a serious side effect. The abdominal pain is almost as bad as the cystitis pain. I feel as if I am caught in a cruel dilemma of choosing one pain or the other. I fear that if I continue taking Pea Pure I may develop an ulcer or some other stomach problem. Has anyone else experienced abdominal pain/heartburn? Does anyone have a strategy for dealing with the stomach side effects?

    1. palmitoylethanolamide4pain | Reply

      heart burn can be triggered by any dietary fat. also by small amounts as a gram or so. just take half the content of the capsule over a meal, or discuss with your doctor and get omeprazol low dose to go with it.

  88. Hi is this compound useful for food allergies, since it’s anti inflammatory? And is it safe for children?

    1. palmitoylethanolamide4pain | Reply

      indeed, as you can read at this site!

  89. Bio identical hormones,is it safe to take pea pure while using bio-identical estrogen and progesterone .thankyou for you’re help ,Anne

    1. palmitoylethanolamide4pain | Reply

      No problem, PEA can be combined with all other compounds

  90. Is cream better to use than pills ? Can it be taken with other medications and supplements? We’re do I get it is it safe and legal ??

    1. palmitoylethanolamide4pain | Reply

      capsules are probably better…and supplements are safe and legal….

  91. Christine Thompson | Reply

    I’m considering using PeaPure for my 42kg 13yr old who has chronic abdominal pain. The trigger was an infection and extensive tests have failed to find an ongoing cause so it is assumed to bee centralised pain.
    I’ve seen the post about safety in children up to 50kg per kg. Is that as a total daily dose?
    Also providing there is a response, does the PeaPure need to be continued long term or can it be stopped and still maintain the improvement?

    1. palmitoylethanolamide4pain | Reply

      Give your son max 3 times daily a capsule, that is sufficient. If he responds you can slowly slowly decrease the dose, each month 1 capsule less. You will notice whether that works! Good Luck!

      1. Christine Thompson

        Thank you 🙂

  92. nancy michelle | Reply

    I had a terrible accident in 2014 since then i have had head trauma and chronic pain. I have tried lyrika and the side effect were too bad the withdrawl even worse. When my pain doctor recommended peapure i was discourage and had no faith in it but finaly decided to order it from Netherland. Afther one week the package arrived in Canada. On the first day of taking i notice i was able to sleep a bit better. It also help with my night terror. It’s been 2 weeks now i take 1 400 am and 2 400 mg pm.
    I can say that the pain has slighly decrease
    i am hoping it will adjust and work as they say over time. I would def recommend it. There is not much review about this product but it is good and is worth a try!

    1. palmitoylethanolamide4pain | Reply

      try to increase the dose if not enough response, or to try PeaPlex instead.

  93. Hello I suffered from an irritation of my pudendal nerve because of my pregnancy four years ago. I was getting better with osteopathic treatment. I had a mycosis that is now gone. The consequence of that mycosis is an allodynia and spontaneous pain down there in particular place from maximum 1 cm. It was seven months ago. Six months ago I began peapure three times 400mg a day during two months. I had no result at all. I continue taking peapure two times 400mg a day because I put so much hope in that product and because my allodynia is terrible. Even the wind can cause pain. Do you think that I should stop the product or try taking 400mg six times a day during a month to see what happens? What can I conclude if peapure is non effective? That the glia cells are not involved in my problem? I am really desperate. I read a lot of scientific publications around peapure and I don’t understand why it doesn’t work for me. I hope you can give me some advices. Not knowing what happens to you is diffucult (not as much as the pain). the creme is not an option because the place is untouchable. thank you for reading me.

    1. palmitoylethanolamide4pain | Reply

      There is sadly enough not one compound working in everyone. There are responders and non-rsponders. I would max the dose to 3 times 2 capsules, and ask your MD to prescribe a compounding cream based on 5% baclofen,( or 10% ketamine cream) to administer topically. And go to a pelvic physio to evaluate. Good Luck!

  94. Hello,
    I’m French and my name is Severine.
    I wanted to know if PEA can work with Lyme.
    I got a neurolyme.
    Thank you for your help.

    Je suis atteinte de la maladie de Lyme, la forme neurologique avec douleurs et gros dysfonctionnements vésical, brulures, décharges, picotementset anesthésie dans les bras et jambes.
    Le PEA pourrais t’il m’aider dans se cas?
    Les soucis de vessie (envies constantes d’uriner, brulures et douleurs) me pose vraiment problème.
    Le PEA pourrait-il atténuer tous ça ?
    Merci de votre aide.

    1. palmitoylethanolamide4pain | Reply

      there are many stories of Lyme patients being happy with PEA!!!

  95. I have SFN and am well into my second month and on the increased dose Of PeaPure. I had a couple of good days but seem to have relapsed. My main symptom is intense itching ( I thought the anti inflammatory properties would help with the itching), stinging and burning…I react badly to cold temperatures.
    Should I persevere with the PeaPure or is it time to give up?

    1. palmitoylethanolamide4pain | Reply

      step over to PeaPLex and double dose to 3 times 2 capsules after a meal!

  96. […] long term treatment, it’s often recommended that patients take Palmitoylethanolamide. Also known as PEA, this drug is a naturally occurring substance that is responsible for a large […]

  97. […] long term treatment, it’s often recommended that patients take Palmitoylethanolamide. Also known as PEA, this drug is a naturally occurring substance that is responsible for a large […]

  98. Would PeaPure do any good for someone newly diagnosed with Ehlers-Danlos syndrome?

    1. palmitoylethanolamide4pain | Reply

      Some patients in the Netherlands used it an found it helpful

    2. I have been diagnosed with Ehlers-Danlos Syndrome and have spondylolisthesis and PEA PURE has worked well on controlling my back and shooting nerve pain. Although it took about 2 months before it took affect, it was worth the wait. I took 3 capsules a day, and once it started working, I now take 2 capsules a day, one in the am and 1 in the pm. I have used it now for about 2 years and have become almost pain free with consistent usage. Hope it works for you.

      1. Thanks, this is most important feed back; in NL there are a few ED patients experiencing the same!

  99. Estimado Señor / Señora:

    ¿Quieres vender tu riñón? ¿Está buscando una oportunidad para vender su riñón por dinero debido a Financial Break Down y no sabe qué hacer, entonces póngase en contacto con nosotros hoy y le ofreceremos buena cantidad para su riñón. Mi nombre es Dr.gomez. Soy un Phrenologist en UBTH Specialist Hospital. Nuestro Hospital está especializado en cirugías renales y también tratamos de compra y trasplante de riñones con un donante correspondiente. Estamos ubicados en España, Reino Unido, Estados Unidos, Malasia. Si usted está interesado en la venta o la compra de riñón por favor no dude en ponerse en contacto con nosotros a través de correo electrónico: (

  100. I have had Trigeminal Neuralgia for 10 years, I have tried almost every medication out there, the combination I am on now works ok, but I still have daily constant pain. I also have nerve damage on one side of my mouth due to a dental procedure, which has left the lower part of my lips, chin , and gums extremely sensitive to anything, even a small gust of wind could send me to my knees with pain. I am curious about the supplements and the cream. Which would you recommend?

  101. […] long term treatment, it’s often recommended that patients take Palmitoylethanolamide. Also known as PEA, this drug is a naturally occurring substance that is responsible for a large […]

  102. Inam guessing PEA is synthesized in a lab like other pharmaceuticals? K

  103. Hi my name is Kim & I live in the USA . I suffer from CRPS (Chronic or Complex) Regional Pain Syndrome aka..RSD. I my right lower leg I also have drop foot this is all due to 4 spinal fusions from L3-4 thru L5-S1. I would love to try this in combination with my pain medication regimen . Do u feel this would help me my leg is on fire burning stabbing swelling so bad that most if not all times it is difficult to walk. I need an answer asap please help.

    1. just try it!

  104. Please tell me how I can order this get it in the USA & on a wed site I can understand please I really need ur help

    1. go Fiteyes

  105. Have you ever successfully treated a patient with Epidural Lipomitosis and Arachnoiditis?

  106. Most AMAZING pain reliever ever ! Chronic lower back n sciatica relieved within 5 minutes of 2x 400 mg capsule in the morning with my coffee. I walk freely, swing my hips with ease and generally feel 20 yrs younger – seem to get 6-8 hrs effect. Another 1 capsule 2 pm n l’m good till bedtime. Why has this not been advertised? this the biggest secret the human race has not heard of. Please get people off harmful organ damaging anti inflammatories & analgesia and lobby politicians to install this on the shelves of supermarkets !!!!! Thankyou Rita & all involved in PeaPures. Manufacture !

    1. happy to hear!!!

  107. Michael Ann Leaver | Reply

    Have you heard of any positive results from people with Erythromelalgia?

    1. worth while to try, but use double dose of a patented micro-PEA variety, and combine it with cream containing 10% phenytoin for a starter, at your compounding pharmacists

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