Palmitoylethanolamide beschermt zenuwen tegen chemokuren

In het boeiende artikel “Antineuropathic Profile of N-Palmitoylethanolamine in a Rat Model of Oxaliplatin-Induced Neurotoxicity” beschrijven farmacologen de bijzondere bschermende en pijnstillende werking van palmitoylethanolamide bij zenuwschade door chemokuren. Hun werk was ingegeven door de positieve resultaten die in de neurologische kliniek van professor Cruccu uit Rome behaald was.

Recently, the efficacy of PEA in chemotherapy-induced painful neuropathy was suggested since Truini et al. demonstrated the efficacy of PEA in relieving pain and improving neurophysiological functions in patients undergoing thalidomide and bortezomib treatment.

This evidence prompted us to investigate the role of PEA treatment in oxaliplatin-induced neuropathic pain. The anti-neuropathic role of PEA was evaluated in oxaliplatin-treated ani- mals by analyzing pain behavior in relation to molecular, morphological and functional protection of the nervous system.

De auteurs vonden wederom, dat PEA niet alleen pijnstillende en ontstekingsremmende werking bezat bij de beschadigde zenuwen, maar ook dat het de zenuwen beschermde tegen de giftigheid van de chemotherapie.

Schermafbeelding 2015-11-24 om 19.06.26

Bovenste: gezonde zenuwen, middelste: zenuwbeschadigingen na chemo, onderste: zenuwen na chemo beschermd met PEA

Zoals te zien is op de afbeeldingen, beschermt PEA de zenuwen tegen de schade van de chemotherapie.

De conclusies waren dat PEA:

  1. pijn stilt
  2. motoriek verbetert
  3. zenuwcellen beschermt
  4. Schwann cellen om de zenuwen heen beschermt
  5. de functie van het ruggenmerg verbetert
  1. PEA significantly reduced oxaliplatin-dependent pain.
  2. Furthermore, an improvement in motor coordination is evidenced.
  3. The pain relief efficacy is maintained after repeated treatment excluding tolerance development.
  4. PEA prevents morphological derangements in nerve cells as well as in the Schwann cells of the peripheral nerve of oxaliplatin-treated-rats.
  5. The protective effects of PEA result in functional normalization highlighted by the electrophysiological measurements performed in the spinal cord.

Bron:

Di Cesare Mannelli L, Pacini A, Corti F, Boccella S, Luongo L, Esposito E, et al. (2015) Antineuropathic Profile of N-Palmitoylethanolamine in a Rat Model of Oxaliplatin-Induced Neurotoxicity. PLoS ONE 10(6): e0128080. doi:10.1371/journal. pone.0128080

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