2 Gram of Palmitoylethanolamide/day effective in neurological disease in horses: Stringhalt’s syndrome

Stringhalt’s syndrome in horses consists of a severe neurologic symptomatology (severe hyperreflection and overt gait inability) being present for at least 6 months and the animals being resistant to coctails with neuro-supportive vitamins.

The 4 horses are orally treated with 2 g/die N-palmitoylethanolamide for 20 days.

The clinical evaluation is carried out before the treatment (t0), after 10 days (t1), 20 days (t2) and 40 days (t3) of treatment. The neurologic recovery with respect to t0 is evaluated at t1, t2 and t3, and in addition a final observation 1 or 2 months (t4) after the end of the treatment for a more complete evaluation.


The results show that, when treated orally with palmitoylethanolamide, the animals display an improvement of neurologic deficit of at least 60%.

Such an improvement was still evident following the evaluation of these animals after 1 to 2 months at the end of the treatment.

Source: Aminoalcohols-N-Acyl derivatives as therapeutical agents against the neurogenic endoneural edema of the peripheral nerve.

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