In an experimental model palmitoylethanolamide and related molecules could protect the brain against ischemic insults such as stroke, by decreasing the permeability of the blood-brain-barrier (BBB). Application of palmitoylethanolamide at 10 μM decreased the insult-induced increase in BBB permeability during reperfusion after stroke.
The conclusion of the authors was that compounds such as palmitoylethanolamide:
“may play an important modulatory role in normal BBB physiology, and also afford protection to the BBB during ischaemic stroke, through a number of target sites.”
From many other studies it was already quite clear, that PEA protects cells and tissues against all kinds of damage, from UV light up to ischemia.
Souce: Hind WH, Tufarelli C, Neophytou M, Anderson SI, England TJ, O’Sullivan SE. Endocannabinoids modulate human blood-brain barrier permeability in vitro. Br J Pharmacol. 2015 Jun;172(12):3015-27.