Adelmidrol, a chemical palmitoylethanolamide analogue, active in inflammation.

As an abstract in ‘Shock’ data are published to support the anti-inflammatory action of adelmidrol. Adelmidrol is a chemical analogue of palmitoylethanolamide (PEA), and also acts as an Aliamide. The molecule was synthesized by Dr Francesco Della Valle, a pupil of the famous Nobel laureate Rita Levi-Montalcini. He and she were more or less the father and the mother of the Aliamides, compounds which can regulate overactive inflammatory cells.

Adelmidrol, a synthetic PEA analogue

Adelmidrol, a synthetic PEA analogue,  created by the group of Dr Della Valle

In the new study, conducted by the group of professor Cuzzocrea, a well known expert in the field of palmitoylethanolamide, a clear anti-inflammatory action was seen of 10 mg adelmidrol/ kg BW in a classic inflammation paradigm.

The aim of this study was to investigate the effect of adelmidrol on the modulation of the inflammatory response in a mouse model of collagen-induced arthritis (CIA). This is a model which is used often in this field. PEA is also active in this model. Plasma levels of the proinflammatory cytokines and chemokines were reduced by adelmidrol, as was the degree of oxidative and nitrosative damage of the joints.

Source: Astract INF/IR-15: Cuzzocrea S, Impellizzeri D, Di Paola R, Casili G, Cordaro M, Esposito E. ADELMIDROL, A PALMITOYLETHANOLAMIDE ANALOGUE, AS A NEW PHARMACOLOGICAL TREATMENT FOR THE MANAGEMENT OF INFLAMMATORY PAIN.

Shock. 2015 Oct;44 Suppl 2:11.

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