Many patients in the world use acetaminophen, but its analgesic effects are not that impressive. However, in relative low doses, there are virtually no side effects. One should take care however, not to exceed 3-4 gram/ day, as the compound might burden the liver.
Now it has been proven, that palmitoylethanolamide can enhance the analgesic effects of acetaminophen.
In a recent study the pharmacological antihyperalgesic interaction between N-palmitoylethanolamide(PEA) and acetaminophen in diabetic rats was evaluated.
The results revealed a concentration-dependent analgesic effect produced by PEA as well as by acetaminophen.
Furthermore, it was demonstrated that the combination produced a synergistic interaction.
These results provide evidence that PEA in combination with acetaminophen could be useful for pain therapy in neuropathic diabetic patients.
Source: Déciga-Campos M, Ortíz-Andrade R. Enhancement of Antihyperalgesia by the Coadministration of N-palmitoylethanolamide and Acetaminophen in Diabetic Rats.
Drug Dev Res. 2015 Jul 27. doi: 10.1002/ddr.21259.