Palmitoylethanolamide reduces blood pressure in a hypertension model: normalization effects and restoring balance

Um die Erde in Wort und BildRecently it was demonstrated that palmitoylethanolamide (PEA), an endogenous PPARα agonist, protects the kidney from the hypertensive injury, through the increase in the antioxidant defense.

A new study focused particularly on mesenteric bed and carotid artery modifications to examine the mechanisms of PEA lowering effect on systolic blood pressure and thus on vascular tone in hypertensive rats.

A significant lowering effect on blood pressure was shown following PEA treatment of hypertensive rats for 5 weeks compared to untreated rats.

The treatment with PEA caused a significant increase in vaso-relaxation in hypertensive rats compared with  untreated rats.

The increase in perfusion pressure was significantly higher in rats treated with PEA compared with untreated rats.

Summary was: long-term treatment of hypertensive rats with PEA alleviates hypertension, by improving vasodilation, through the modulation of amongst others the renin-angiotensin system in the vasculature.

The major finding, besides PEA-induced reduction of blood pressure, was the capability of PEA to improve of vasodilator function by acetylcholine in pre-constricted mesenteric bed from hypertensive rats.

The conclusion was that PEA may be considered a supplemental approach to blockade of the renine-angiotensive system. This state-of-affairs supports the notion that a combined therapeutic strategy of the aforementioned anti-hypertensive drugs and PEA would be more efficacious, since the ACE inhibition would be strengthened through the reduced expression of these drug targets by PEA.

This is again prove that PEA regulates disturbances in balance in animal systems, even on the level of blood pressure.

Source: Mattace Raso G, Pirozzi C, d’Emmanuele di Villa Bianca R, Simeoli R, Santoro A, Lama A, et al. (2015) Palmitoylethanolamide Treatment Reduces Blood Pressure in Spontaneously Hypertensive Rats: Involvement of Cytochrome P450-Derived Eicosanoids and Renin Angiotensin System. PLoS ONE 10(5): e0123602. doi:10.1371/journal.pone.0123602

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