Palmitoylethanolamide reduces nitrite production in dementia model

PEA reduces nitrite in an Alzheimer model

PEA reduces nitrite in an Alzheimer model

Alzheimer dementia is characterized by toxic proteins in the brain, beta-amyloid is most known. These toxic compounds induce an inflammation of the nervous tissue, and this again destroys nerve cells. Basically this is the reason why people suffer from loss of memory and disturbances of orientation.

Dr M. Cipriano wrote a a Ph.D: STUDIES IN PHARMACEUTICAL SCIENCE, ALIAmides: EXPERIMENTAL STUDIES ON THE CONTROL OF ANGIOGENESIS and from that PhD thesis the following.

She found that cell stimulation with beta-amyloid protein (Aβ (1-42), 1μg/mL) for 48 hours, caused a significant (P<0.001) increase of nitrite levels in comparison to the control cells.

After beta- amyloid (Aβ) stimulation glial cells undergo to reactive gliosis characterized by an increase of cell functionality and the release of several pro-inflammatory mediators, such as nitrite.

Treatment with palmitoylethanolamide (PEA) (10-8; 10-7; 10-6M) significantly and in a concentration dependent manner reduced the nitrite production. This is one of the mechanisms of PEA to counteract nerve inflammation and reactive gliosis.

Nitrite is a molecule that induces inflammation and thus creates brain nerve pathology.

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