Palmitoylethanolamide verlaagt bloeddruk en beschermt de nieren

Hoge bloeddruk beschadigt de nieren. Palmitoylethanolamide verlaagt die verhoogde bloeddruk en beschermt meteen de nieren door het celbeschermende effect van deze lichaamseigen stof:

Palmitoylethanolamide (PEA), a peroxisome proliferator-activated receptor-α agonist, has been demonstrated to reduce blood pressure and kidney damage secondary to hypertension in spontaneously hypertensive rat (SHR).

Dit zijn gloednieuwe bevindingen die samen met we al weten over de beschermende werking van PEA behoorlijk indrukwekkend zijn.

De conclusie is dat PEA vaker ingezet zou moeten worden, omdat het significant zou bijdragen:

This state-of-affairs supports the notion that a combined therapeutic strategy of the aforementioned anti-hypertensive drugs and PEA would be more efficacious, since the ACE inhibition or AT1 blocking, would be strengthened through the reduced expression of these drug targets by PEA.

2015-Raso-Palmitoylethanolamide Treatment Reduces Blood Pressure in Spontaneously Hypertensive Rats- Involvement of Cytochrome P450-Derived Eicosanoids and Renin Angiotensin System

Mattace Raso G, Pirozzi C, d’Emmanuele di Villa Bianca R, Simeoli R, Santoro A, Lama A, Di Guida F, Russo R, De Caro C, Sorrentino R, Calignano A, Meli R. Palmitoylethanolamide treatment reduces blood pressure in spontaneously hypertensive rats: involvement of cytochrome p450-derived eicosanoids and Renin Angiotensin system.
PLoS One. 2015 May 7;10(5):e0123602. doi: 10.1371/journal.pone.0123602. eCollection 2015

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