Palmitoylethanolamide: lowers doses of morphine, oxycodon and other opiates needed

The development of palmitoylethanolamide, an endogenous fatty acid amide, as an FDA-approved prescription drug in the USA has started by a small company, Prismic. This is a result of recent data confirming that palmitoylethanolamide demonstrate a clinical “entourage” or synergistic effect when administered in combination or concomitantly with certain analgesics such as THC, oxycodone, morphine, and other opiates.

This has a clear clinical benefit in that lower doses of the analgesic drugs are required to achieve the desired therapeutic effect. Thus the risk on classical opioid adverse events is reduced, as well as the risk of dependency and tolerance.

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