Lipid messengers such as palmitoylethanolamide may play an important modulatory role in normal Blood Brain Barrier (BBB) physiology, and also afford protection to the BBB during ischaemic stroke, through a number of target sites.
These lipid messengers alter permeability at various epithelial barriers, and receptros as well as levels are elevated by stroke, with potential neuroprotective effects.
The authors explored the role of usch lipid messengerss in modulating blood brain barrier (BBB) permeability in normal conditions and in an ischaemia/reperfusion model.
Br J Pharmacol. 2015 Feb 5. doi: 10.1111/bph.13106. [Epub ahead of print]
Endocannabinoids modulate human blood-brain barrier permeability in vitro.
Hind WH1, Tufarelli C, Neophytou M, Anderson SI, England TJ, O’Sullivan SE.