Oleoylethanolamide and palmitoylethanolamide synthesis in obese individuals and increases after gastric bypass chirurgy

IMG_4571Morbid obese subjects (n=11) were submitted to gastric bypass surgery (GBS) and followed up for one year. Insulin resistance and circulating and subcutaneous adipose tissue (SAT) levels of oleoylethanolamide and palmitoylethanolamide, adipocytokines and CC chemokines were assessed pre- and post-GBS and compared to a control group of normal and overweight subjects (CTL) (n=20)

In subcutaneous adipose tissue, increased expression of resistin, CCL2, CCL5 and tumour necrosis factor and reduced MGLL were shown in morbid obese patients pre-GBS when compared to CTL.

Gastric bypass surgery increased levels of oleoylethanolamide and palmitoylethanolamide and reduced adipocytokines and CC chemokines.

In morbid obese SAT, inverse correlations independent of body mass index were shown between palmitoylethanolamide (PEA) and N-oleoylethanolamide (OEA) levels and inflammatory molecules.

Source:

Montecucco F1, Lenglet S, Quercioli A, Burger F, Thomas A, Lauer E, da Silva AR, Mach F, Vuilleumier N, Bobbioni-Harsch E, Golay A, Schindler TH, Pataky Z. Gastric bypass in morbid obese patients is associated with reduction in adipose tissue inflammation via N-oleoylethanolamide (OEA)-mediated pathways. Thromb Haemost. 2014 Nov 20;113(3).

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