Mast Cell Function: A New Vision of an Old Cell

Mastopedia Research Feed

http://jhc.sagepub.com/content/62/10/698.long

J Histochem Cytochem October 2014 vol. 62 no. 10 698-738

Elaine Zayas Marcelino da Silva, Maria Célia Jamur, Constance Oliver

Abstract

Since first described by Paul Ehrlich in 1878, mast cells have been mostly viewed as effectors of allergy. It has been only in the past two decades that mast cells have gained recognition for their involvement in other physiological and pathological processes. Mast cells have a widespread distribution and are found predominantly at the interface between the host and the external environment. Mast cell maturation, phenotype and function are a direct consequence of the local microenvironment and have a marked influence on their ability to specifically recognize and respond to various stimuli through the release of an array of biologically active mediators. These features enable mast cells to act as both first responders in harmful situations as well as to respond to changes in their environment…

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