Differential release of mast cell mediators and the pathogenesis of inflammation

Mastopedia Research Feed


Immunol Rev. 2007 Jun;217:65-78.

Theoharides TC, Kempuraj D, Tagen M, Conti P, Kalogeromitros D.

Erratum in

Immunol Rev. 2007 Oct;219:204.


Mast cells are well known for their involvement in allergic and anaphylactic reactions, during which immunoglobulin E (IgE) receptor (Fc epsilon RI) aggregation leads to exocytosis of the content of secretory granules (1000 nm), commonly known as degranulation, and secretion of multiple mediators. Recent findings implicate mast cells also in inflammatory diseases, such as multiple sclerosis, where mast cells appear to be intact by light microscopy. Mast cells can be activated by bacterial or viral antigens, cytokines, growth factors, and hormones, leading to differential release of distinct mediators without degranulation. This process appears to involve de novo synthesis of mediators, such as interleukin-6 and vascular endothelial growth factor, with release through secretory vesicles (50 nm), similar to those in synaptic transmission. Moreover, the…

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