Palmitoyethanolamide (Palmidrol) had been explored from the early 70s of last century in infectious diseases adn as a prophylactic therapy for flur and respiratpry infections such as common cold. To products were available with these indications, Impulsin and Palmidrol. Due to many reasons these formulations disappeared again till a new wave of PEA research reactivated the interest in PEA for immunesupport. Now PEA can be considered as a breakthrough natural therapy for flu and common colds. A specific formulation of PEA is also available for the treatment of flu and common cold.
This new Retrospective observational study proves that a palmitoylethanolamide-formulation prevents recurrent respiratory infections in children. It also suggests that PEA can reduce the need for antibiotic treatment, which is a really important message.
The pediatricians Nigro A, Nicastro A, Trodella R conducted an retrospective observational clinical study, in 167 children, aged 3 to 7 years with a clinical history of recurrent respiratory infections, administered with a nutritional product containing palmitoylethanolamide.
The goal of the study was to compare the supplementation containing PEA with the supplementation with certain bacterial extracts on the frequency of episodes of respiratory infection that had resulted in a prescription for antibiotics.
Results: less antibiotics and less excacerbations
The results showed a greater reduction in the frequency of respiratory infections with antibiotic therapy in the group of children supplemented with the PEA supplement than in the group treated with bacterial extracts.
In particular, it was observed that 49.3% of the children using the PEA supplemented, against 5% of those supplemented with extracts, had no infectious episodes requiring the administration of an antibiotic.
100% of subjects supplemented with the PEA supplement have had no more than two episodes of respiratory infection, while this condition, in the cohort treated with bacterial extracts, was observed in only 51% of cases.
These results add to the database supporting PEA’s positive effects in respiratory infections and points out its putative relevance in reducing the amount of antibiotics prescribed.
Authors: Nigro A, Nicastro A, Trodella R Retrospective observational study to investigate Sinerga, a multifactorial nutritional product, and bacterial extracts in the prevention of recurrent respiratory infections in children. Int J Immunopathol Pharmacol. 2014 Sep;27(3):455-460