Mast cells and inflammation

Mast cells are one of the main cells in many pathological inflammation cascades, as pointed out and the supplement palmitoylethanolamide brings mast cells to rest

Mastopedia Research Feed

http://www.sciencedirect.com/science/article/pii/S0925443910002929

Biochimica et Biophysica Acta (BBA) – Molecular Basis of Disease, Volume 1822, Issue 1, January 2012, Pages 21–33

Theoharis C. Theoharides, Konstantinos-Dionysios Alysandratos, Asimenia Angelidou, Danae-Anastasia Delivanis, Nikolaos Sismanopoulos, Bodi Zhang, Shahrzad Asadi, Magdalini Vasiadi, Zuyi Weng, Alexandra Miniati, Dimitrios Kalogeromitros

Abstract

Mast cells are well known for their role in allergic and anaphylactic reactions, as well as their involvement in acquired and innate immunity. Increasing evidence now implicates mast cells in inflammatory diseases where they are activated by non-allergic triggers, such as neuropeptides and cytokines, often exerting synergistic effects as in the case of IL-33 and neurotensin. Mast cells can also release pro-inflammatory mediators selectively without degranulation. In particular, IL-1 induces selective release of IL-6, while corticotropin-releasing hormone secreted under stress induces the release of vascular endothelial growth factor. Many inflammatory diseases involve mast cells in…

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