Palmitoylethanolamide protects mitochondrial structure after bacterial infection

In a biological model with isolated mitochondria, pretreatment with palmitoylethanolamide reduced swelling of mitichondria after inocculation with streptococci. This elegant model was used on 1973 already to demonstrate the protective effects of PEA during infections on subcellular level.

Image

The authors stipulated that the effect of PEA treatment on both types of swelling was observed even 1 week after the last dose of PEA, and the reduction was by 50 percent. They stated:

Thus the PEA treatment of mice, which resulted in the characteristic changes in mitochondrial fatty acids, markedly decreased the swelling responses of liver mitochondria to orthophosphate and staphylococcal toxin.

They included experiments using the changes of relative fluorescence in mitochondria from control as a marker and found that:

PEA-treated animals after preincubation with staphylococcal toxin support the idea of increased resistance to this toxin by mitochondrial membranes from mice fed palmitoylethanolamide.

Source: HANA OBERMAJEROVA, KAREL MASEK, JAROSLAV SEIFERT, EVSSBN, EFZEN BUCHAR: STRUCTURAL AND FUNCTIONAL CHANGES IN LIVER
MITOCHONDRIA OF MICE FED  PALMITOYLETHANOLAMIDE (PEA). Biochemical Pharmacology, Vol. 22. pp. 2529-2536. Pargamon Pras, 1973.

Now PEA can also be considered as a breakthrough natural therapy for flu and common colds.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

%d bloggers like this: