In a biological model with isolated mitochondria, pretreatment with palmitoylethanolamide reduced swelling of mitichondria after inocculation with streptococci. This elegant model was used on 1973 already to demonstrate the protective effects of PEA during infections on subcellular level.
The authors stipulated that the effect of PEA treatment on both types of swelling was observed even 1 week after the last dose of PEA, and the reduction was by 50 percent. They stated:
Thus the PEA treatment of mice, which resulted in the characteristic changes in mitochondrial fatty acids, markedly decreased the swelling responses of liver mitochondria to orthophosphate and staphylococcal toxin.
They included experiments using the changes of relative fluorescence in mitochondria from control as a marker and found that:
PEA-treated animals after preincubation with staphylococcal toxin support the idea of increased resistance to this toxin by mitochondrial membranes from mice fed palmitoylethanolamide.
Source: HANA OBERMAJEROVA, KAREL MASEK, JAROSLAV SEIFERT, EVSSBN, EFZEN BUCHAR: STRUCTURAL AND FUNCTIONAL CHANGES IN LIVER
MITOCHONDRIA OF MICE FED PALMITOYLETHANOLAMIDE (PEA). Biochemical Pharmacology, Vol. 22. pp. 2529-2536. Pargamon Pras, 1973.