Palmitoylethanolamide has been mentioned as a new intervention to reduce infections in the brain and increase resistance against bacteria. In a recent (2014) article titled:
Strategies to increase the activity of microglia as efficient protectors of the brain against infections.
German bacetriologists and neuropathologists hypothised that based on the ability of microglial cells to phagocytose and kill pathogens and on clinical findings in immunocompromised patients with CNS infections, an intact microglial function is crucial to protect the brain from infections. They mentioned a number of such microglia stimulating strategies. They refer to palmitoylethanolamide (PEA), an endogenous lipid, and mentioned its increased phagocytosis of bacteria by microglial cells in vitro.
Nau R1, Ribes S2, Djukic M1, Eiffert H3. Strategies to increase the activity of microglia as efficient protectors of the brain against infections. Front Cell Neurosci. 2014 May 22;8:138. doi: 10.3389/fncel.2014.00138. eCollection 2014.