PALMITOYLETHANOLAMIDE CONTROLS THE PRO-ANGIOGENIC PATHWAY INDUCED BY BETA AMYLOID IN GLIAL CELLS

AT the 34° Congresso Nazionale della Società Italiana di Farmacologia in Rimini, Palacongressi, 14-17 Ottobre 2009 Mariateresa Cipriano and colleagues presented data on the role of PEA in vitro, in the modulation of angiogenetic response in Abeta-challenged glial cells.(Alzheimer model).

Glial cells were cultured in 10% FCS supplemented DMEM and treated with 1 mg/mL of Ab (1-42) in the presence of PEA, at concentration of 10-8 to 10-6 molair.

Results:

PEA reduced the pro-angiogenic response induced by beta amyloid-stimulus in glial cells. PEA treatment decreased both the transcription and expression of the main vasoactive factor, VEGF. Moreover, PEA reduced the expression of an other essential pro-angiogenic mediator, TNF-a, and the presence of MMP-9, a protein strongly involved in the degradation of extracellular matrix, necessary to allow the vessel progression.

Source: Mariateresa Cipriano°+, Caterina Scuderi#, Daniele De Filippis°+, Giuseppe Esposito#, Vincenzo Di Marzo*+, Luca Steardo# and Teresa Iuvone°+: PALMITOYLETHANOLAMIDE CONTROLS THE PRO-ANGIOGENIC PATHWAY INDUCED BY BETA AMYLOID IN GLIAL CELLS

+Endocannabinoid Research Group; °Department of Experimental Pharmacology, Faculty of Pharmacy, University of Naples “Federico II”; *Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Naples, #Department of Physiology and Pharmacology “Vittorio Erspamer”Faculty of Pharmacy University of Rome “La Sapienza”.

34° Congresso Nazionale della Società Italiana di Farmacologia
Titolo abstract: Effects of palmitoylethanolamide on the developmen… Esposizione: Simposio Sessione: palmitoylethanolamide ANTINFLAMMATORY/ NEUROPROTECTIVE PROPERTIES: THE PHARMACOLOGICAL BASES FOR NOVEL PUTATIVE THERAPEUTIC AGENTS S-2/4
http://www.sifweb.org/cong34/abs_stato.php

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