In the presentation: Palmitoylethanolamide prevents metabolic alterations and restores leptin sensitivity in ovariectomized rats, at the 36° CONGRESSO NAZIONALE DELLA SOCIETÀ ITALIANA DI FARMACOLOGIA; Il ruolo della RICERCA farmacologica per la CRESCITA e la SALUTE in Italia, Torino, 23-26 ottobre 2013, Santoro er al presented data supporting PEA’s role in obesitas. In ovariectomized rats obesitas happens (comparable with postmenopausal weight gain). In these rats chronic administration of PEA causes a time-dependent decrease of food intake and body weight, accompanied by a reduction of fat mass.Histological analysis of white adipose tissue also revealed a hypertrophic phenotype in OVX animals, which was reverted by PEA treatment.
PEA thus reverses adipositas related physiological changes. The final conclusion was:
The reduction of weight gain induced by PEA is also accompanied by a reduced inflammatory state of the macrophagic infiltrate in white adipose tissue and cytokine production responsible of the metabolic dysfunctions associated with obesity-linked disorders.