At the 34° Congresso Nazionale della Società Italiana di Farmacologia in Rimini, Pala-congressi, 14-17 Ottobre 2009, Professor B. Costa presented PEA’s ANTIALLODYNIC AND ANTIHYPERALGESIC EFFECTS IN A MURINE MODEL OF NEUROPATHIC PAIN.
The efficacy of PEA was tested in vivo in two murine model of neuropathic pain, the chronic constriction injury of the sciatic nerve (CCI) and the STZ-induced diabetic neuropathy. PEA (10 mg/kg) was administered i.p. to mice once a day for one week, starting the day after the lesion. PEA treatment resulted in reduction of both thermal hyperalgesia and mechanical allodynia.