Immune mediators of chronic pelvic pain syndrome

Chronic pelvic pain syndome tends to be an expansion from IC or vulvodynia, on its way to become fibromyalgia or CWP, immune mediators can indeed shed light on the pathogenesis of these pain states.

Mastopedia Research Feed

Nat Rev Urol. 2014 Apr 1. doi: 10.1038/nrurol.2014.63. [Epub ahead of print]

Murphy SF, Schaeffer AJ, Thumbikat P.


The cause of chronic pelvic pain syndrome (CPPS) has yet to be established. Since the late 1980s, cytokine, chemokine, and immunological classification studies using human samples have focused on identifying biomarkers for CPPS, but no diagnostically beneficial biomarkers have been identified, and these studies have done little to deepen our understanding of the mechanisms underlying chronic prostatic pain. Given the large number of men thought to be affected by this condition and the ineffective nature of current treatments, there is a pressing need to elucidate these mechanisms. Prostatitis types IIIa and IIIb are classified according to the presence of pain without concurrent presence of bacteria; however, it is becoming more evident that, although levels of bacteria are not directly associated with levels of pain, the presence of…

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