Neuroprotective Properties of Peroxisome Proliferator-Activated Receptor Alpha (PPARα) and its Lipid Ligands

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Under this title 3 pharmacologists reviewed the important protective properties fof natural lipid ligands such as palmitoylethanolamide. In science more and more experts are impressed by what natural molecules such as palmitoylethanolamide can do for our body. They are age old, not to say million old protective molecules, which reset the nucleus of our cells in case of damage, from an alarm phase into a reparation phase.

So also the pharmacologists of this paper, who state:

This PPAR receptor and its endogenous ligands, including oleoylethanoloamide (OEA) and palmitoylethanolamide (PEA), are involved in physiological and pathological responses, such as satiety, memory consolidation, and modulation of pain perception. The protective role of PPARα agonists in neurodegenerative diseases and in neuropsychiatric disorders makes manipulation of this pathway highly attractive as therapeutic strategy for neuropathological conditions.

Source: Fidaleo M, Fanelli F, Ceru MP, Moreno S. Neuroprotective Properties of Peroxisome Proliferator-Activated Receptor Alpha (PPARα) and its Lipid Ligands. Curr Med Chem. 2014 Mar 3.

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