Pudendal neuralgia is the most common and most disabling form of pelvic pain. It presents as unilateral or bilateral burning pain of the anterior or posterior perineum that is worse on sitting and relieved by standing, not usually associated with night pain. This pain is a cause of chronic, disabling, and often intractable perineal pain. Treating this pain is very difficult. Palmitoylethanolamide ( PeaPure) is an innovation in this field.
The authors report a case of a 40-year-old man presenting with chronic pelvic pain due to pudendal nerve entrapment, successfully treated with our body-own analgesic palmitoylethanolamide (PEA, een PEA-houdend product; PeaPure). Their hypothesis of its mechanism of action in this ailment is:
PEA may induce relief of neuropathic pain through an action upon receptors located on the nociceptive pathway as well as a more direct action on mast cells via an ALIA (autocoid local injury antagonism) mechanism. 
They conclude stating that: the present case suggests that PEA could be a valuable pharmacological alternative to the most common drugs (anti-epileptics and antidepressants) used in the treatment of neuropathic pain.
PEA is an endogenous mediator whose levels are increased following neuroinflammatory or neuropathic conditions in both animals and humans, possibly to exert a local anti-inflammatory and analgesic action.
There are meanwhile quite some products containing PEA: PeaPure is the purest form and most well known in the USA. It can be ordered by a pharmacy in La Jolla: PJ Presciption shoppe. On their website it is read:
We are proud to be the only pharmacy in the United States to stock Peapure capsules, a dietary supplement which we import from The Netherlands. Peapure contains 400 mg palmitoylethanolamide per capsule and comes in boxes of 30 capsules each.
More information on Peapure can be found on many sites online. We recommend looking at the supplement manufacturer’s website, a pain specialist’s website, and a freely accessible scientific review article. Since Peapure is a supplement it does not require a prescription and we can ship it to your home, anywhere in the United States.
Our price is $32 + tax per box and a flat rate of $4 for shipping.
If you are interested in ordering, please call us at 619 223 5404 (out-of-state customers can dial 855 698 2590 – toll-free) and let us know your name, address, phone number and credit card information.
Many different painstates have been successfully treated with PEA, without bothersome side effects, drug interactions and no dose adjustments necessary for the elderly and renal patients.
Recommended starting dose: 3 times 400 mg/day. After 2-4 weeks double dose if necessary.