MCP-1-Induced Histamine Release from Mast Cells Is Associated with Development of Interstitial Cystitis/Bladder Pain Syndrome in Rat Models

P1080799

Chronic Bladder Syndrome can be treated with PEA 1200 – 2400 mg/day; this brings the mast cells to rest.

Interstitial Cystitis or chronic bladder syndrome (or bladder pain syndrome) is associated with a number of symptomatic sequelae that are poorly understood on a mechanistic level. The current study provides evidence suggesting that MCP-1-induced increases in histamine release are associated with CCR2 surface proteins on Mast Cells and are involved in the development and progression of IC/BPS.

More info on chronic bladder pain and its treatment

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http://www.hindawi.com/journals/mi/2012/358184/

Mediators of Inflammation, Volume 2012 (2012), Article ID 358184, 9 pages

http://dx.doi.org/10.1155/2012/358184

Jianwei Lv, Yiran Huang, Shiguo Zhu, Ganggang Yang, Yujian Zhang, Jing Leng, Juanjie Bo, and Dongming Liu

Abstract

Objective. Interstitial cystitis/bladder pain syndrome (IC/BPS) is characterized by overexpression of monocyte chemoattractant protein-1 (MCP-1) in bladder tissues and induction of mast cell (MC) degranulation. This study was undertaken to explore the mechanism of action of MCP-1 in the development of IC/BPS. Methods. A rat model of IC/BPS was developed by perfusing bladders of nine SPF- grade female Sprague-Dawley rats with protamine sulfate and lipopolysaccharide (PS+LPS). MCP-1 and histamine levels in bladder tissue and urine were detected by immunohistochemistry and ELISA. MC degranulation was measured by immunofluorescence techniques and chemokine (C-C motif) receptor 2 (CCR2) was assayed by flow cytometry. Results. Increased MCP-1 expression in bladder tissue and elevated MCP-1 and histamine levels were observed in the urine of…

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