Vitamin B6 intoxication, painfull neuropathy and treatment with palmitoylethanolamide


A patient complained about sever pain in the legs, pain-score 8 out of 10 in 2011. She went to a neurologist who examined her and conducted an EMG. The EMG was disturbed and showed signs of axonal neuropathy. Her vitamin B6 levels in the blood were much to high and the doctor adviced to stop taking the vitamin B6 supplement she took for some years.

This issue of getting a peripheral painful neuropathy is a problem, as patients not always understand they are taking a vitamin B6 supplement…

This patient used a supplement named NTM-glutathion Plus. This contained 3500% of the normal daily dose for some years.

Her family doctor was not aware of the nasty side effects of a high dose B6 and told her the vitamin B6 levels were OK; he thought the values were not too Low….But he did not know the values can be much too high…. which is bad…

The pain did not vanish after stopping B6 for 2 years. This is comparable to the case described hereunder.

Patient was treated with PEAPure and within 2 months the pain-scores were decreased from 8 to 2-3.

PEA seems a good option to treat vitamin B6 intoxications.

Q and A related to B6

What to do if taking B vitamins?

Always check the B6 level on the package insert or label, be sure the B6 level is not above 300% of the daily dose!

What to do if I get tingling and pain and take a vitamin B supplement?

Check the label for B6, if B6 is higher than 300% stop the supplement, but only after you had your blood level of B6 taken by your doctor. Normal range is somewhere between 15 to 73 mmol. Higher than 100 mmol is no good.

What to do if I took B6 too high for a long period of time?

Stop immediately (but always check the blood before stopping) and if you have symptoms of polyneuropathy (pain, pins and needlse, numbness, tingling) start PeaPure 400 mg 3 times daily for at least 3 months…

Polyneuropathy induced by B6 can sometimes be irreversible… we found that PEA can sometimes reverse this irreversibility like in the above described patient…

Here an entry of a comparable B6 case from a blog:

I would like to talk to anyone out there who has significantly elevated vitamin B6 levels and who also has been diagnosed peripheral neuropathy.

I went to see a neuro 4 years ago because of complaints of mild numbness in hands and feet, burning (sunburnt type sensations) worse when covered with shoes and in hot climates; flushing of skin (especially in the legs); instability and heaviness in legs; diminished reflexes, etc.

My nerve conduction tests were abnormal when tested. The neuro called it idiopathic polyneuropathy. I also have mild Hashis (which according to my own record keeping) probably starting in the lates 90’s when I used to have a TSH of 1.62 (the lowest I know of for which I have records), but is now bordering at or above 4 for the past 7 or so years. I also have significantly elevated antibodies (both types Anti-TPO, Anti-TG), and mild enlargement of the right thyroid lobe.

I have only been on thyroid meds (both natural and synthetic) for the past few years, but have still not been getting good results and am still trying to get this sorted out and optimized. Two years after seeing my neuro, I asked to have a Vitamin B6 serum test done (not a standard test here) – through my Naturopath, which I had to research on my own and get done through a major Canadian Centre. Most docs did not even know it was available (not even my neuro). It turns out that my levels were 10 times higher than the upper range of normal. I had seen a Naturopath about 15 years ago, and was given Solaray Multis to take. I was also taking a men’s multi later (when Solaray was no longer available in Canada). I believe these multis had up to 50mgs of B6 as a daily dose. As soon as I found out about my B6 levels I stopped the multis altogether. It has taken about 1 year, and my levels are now about 150% of the normal range (much less than the original test). Of course we all believe that B6 is ‘supposed’ to be water soluble and go right through you, but for some reason this did not happen for me. When I told my neuro about this and showed him a copy of the test he was surprised. He knew of no cases of vitamin induced neuropathy on such low levels of B6. Anyway, my symptoms have not changed at all in 4 years, in some cases I think they are worse.

Long story short, for those of you that have B6 elevations and peripheral neuropathy, what are your symptoms EXACTLY? Since I have other health issues complicating the matter, I am trying to figure out how much of my neuropathy is based on the B6 versus thyroid/metabolic issues, etc. If you could let me know what your hands and feet feel like exactly, it would be very helpful to me, as well as any other symptoms that you may have and what if anything you are doing about it. It’s been a struggle for me through all of this. I used to be the picture of health, boundless energy. I have always taken care of myself, never smoked, non-drinker, eat healthy, gym regular, etc. So I’d like to start some dialogue on those in the same boat.

One response

  1. Hi, I recently, about 2 months ago started having pins and needles, numbness, some leg pain and fingertip sensitivity symptoms. Came out of nowhere. Had been on a multi-vitamin with 300% daily value for a while. mt Doc ran my B6 and the value 42 ng/ml (Normal is 2.1 -21.7) so double the normal top range. Recently had NCV and EMG and passed both. Next step is do I have small fiber neuropathy or is the B6 levels. That’s where I am now. I feel great otherwise. I’ve been told folks with small fiber cannot feel the pin prick test on their toes as well as having no ankle break reflexes so I’m hopeful at this point its the B6 which I have stopped taking as of 5 days ago. A noraml person should not have double the high value just taking a single multi but maybe in some of us it builds in the body over time??

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