Attenuation of this sensitization by PEA suggests a possible option for acute management of craniofacial pain and headache, suggested by Drs Cairns et al in their 2014 article on:
Intraganglionic injection of a nitric oxide donator induces afferent mechanical sensitization that is attenuated by palmitoylethanolamide.
The authors used a special model for headache, based on the the nitric oxide (NO) donator diethylenetriamine/nitric oxide (DETA/NO). This compound triggers headache by increasing the release of prostaglandin E2 by trigeminal satellite glial cells (SGCs).
Intravenous administration of PEA (1 mg/kg) or ketorolac (0.5 mg/kg) prevented DETA/NO-induced afferent mechanical sensitization. The comparison of PEA with a NSAID in this model is quite interesting. The authors concluded:
Elevation of NO in the trigeminal ganglion results in the sensitization of the peripheral endings of masticatory muscle nociceptors to mechanical stimulation through a mechanism that involves prostaglandin E2 release from SGCs. Attenuation of this sensitization by PEA suggests a possible option for acute management of craniofacial pain and headache.
Practical use of PEA in headache
In this study pure PEA was used; pure PEA is present in the supplement PeaPure. These capsules contain 100% pure PEA and nothing else. ( As reported by the producer: ‘We opt for controlled quality All our products are checked for purity in an independent laboratory. The Report of Analysis can be found on the website. Consequently, none of our products contain any chemical additives, flavorings, coloring agents or sweeteners. Read the report with the PEA analysis here’.)
The practical use of this study adds to the experience in the field with PEA dosing in migraine and headache. The advice is to take PEA in acute headache situations as powder, for instance from the PeaPure capsules, and put it under the tongue for direct resorption. Keep the powder in the mouth till it is vanished. The users report that the powder disappears in some minites, it is tasteless and once in the blood it counteracts the headache.
Cairns BE, Laursen JC, Dong XD, Gazerani P. Intraganglionic injection of a nitric oxide donator induces afferent mechanical sensitization that is attenuated by palmitoylethanolamide. Cephalalgia. 2014 Feb 11.