The scientific group of professor D. Piomelli (USA) looks for new ways to enhance palmitoylethanolamide in cells. To help these cells against injury. In their recent article:
Synthesis, Structure-Activity, and Structure-Stability Relationships of 2-Substituted-N-(4-oxo-3-oxetanyl) N-Acylethanolamine Acid Amidase (NAAA) Inhibitors
they described new molecules of class of α-amino-β-lactones as new important and selective NAAA inhibitor. These molecules have been shown to have a clear anti-inflammatory effects. These effects are mediated through palmitoylethanolamide- activation of PPAR-α.
It will however take 10 more years before any of these molecules will enter the clinic, if ever. In the mean time the substitution with palmitoylethanolamide is proven to be the best way to supply the body with this protective molecule. Dose recommendation as a starting dose: 3 times 400 mg/daily.
Vitale R, Ottonello G, Petracca R, Bertozzi SM, Ponzano S, Armirotti A, Berteotti A, Dionisi M, Cavalli A, Piomelli D, Bandiera T, Bertozzi F. Synthesis, Structure-Activity, and Structure-Stability Relationships of 2-Substituted-N-(4-oxo-3-oxetanyl) N-Acylethanolamine Acid Amidase (NAAA) Inhibitors.
ChemMedChem. 2014 Jan 8. doi: 10.1002/cmdc.201300416.