Effect of oral palmitoylethanolamide in a murine model of colitis

Schermafbeelding 2013-12-28 om 18.02.52Recently an abstract was published on the oral efficacy of PEA in a colon inflammation model. Colitis was induced in mice by intracolonic administration of dinitrobenzene sulphonic acid (DNBS) and inflammation was assessed by evaluating inflammatory markers/parameters (colon weight/colon length ratio and myeloperoxidase activity). A potential ‘curative effect’ on inflammation was tested:

1) in a first experiment, where PEA (0.1-1 mg/kg) was administered intraperitoneally (i.p.) for three consecutive days starting 24 hours after DNBS administration; and

2) in a second experiment, where PEA (0.1-1 mg/kg) was administered orally (per os) for three consecutive days starting 24 hours after DNBS administration.

Results:

1) in the first experiment PEA (i.p.) inhibited the loss of body weight induced by DNBS administration and reduced colon weight/colon length ratio in a dose-dependent manner; and

2) in the second experiment PEA (per os) inhibited the loss of body weight induced by DNBS, reduced colon weight/colon length ratio and myeloperoxidase activity, as well as the number of animals with diarrhea.

In conclusion, these results suggest a massive curative effect of PEA in a murine model of IBD.

Effect of palmitoylethanolamide in a murine model of colitis

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