Palmitoylethanolamide tegen Alzheimer dementie

PEA tegen ALzheimer

In een recent artikel werd de aandacht gericht op de rol die PEA kan spelen bij de behandeling van Alzheimer dementie, door op meerdere niveaus in te grijpen. Zo kan zowel de neuroinflammatie als de stoornissen van het geheugen aangepakt worden. De auteurs stelden:

… PEA has multiple physiological roles including involvement in learning and memory, neuroinflammation, oxidative stress, neuroprotection and neurogenesis. Compounds such as PEA have also been implicated in the pathology of, or perhaps protective responses to, neurodegenerative diseases. This is particularly the case with Alzheimer’s disease, the most common age-related dementia associated with impairments in learning and memory accompanied by neuroinflammation, oxidative stress and neurodegeneration.

This review examines the evidence supporting the roles that PEA and PEA like molecules appear to play in Alzheimer’s disease and the potential for beneficial therapeutic manipulation of the endogenous lipid-signalling system.

Bron: Maroof N, Pardon MC, Kendall DA. Endocannabinoid signalling in Alzheimer’s disease. Biochem Soc Trans. 2013 Dec 1;41(6):1583-7. doi: 10.1042/BST20130140.

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