Even much used pharmaceutical painkiller paracetamol (acetaminophen, Tylenol) has troublesome side-effects and can lead to death!

The importance of a natural painkiller such as palmitoylethanolamide, a endogenous molecule with no side effects of any importance became again clear, after finding that the most use pharmaceutical painkiller, paracetamol (acetaminophen, Tylenol) can lead to death as a side effect:

More than 150 Americans die each year from accidental acetaminophen poisoning, while tens of thousands are hospitalized for overdosing on the painkiller, according to an investigative series by ProPublica. The report says the FDA has been slow to act in protecting consumers, and the manufacturer has argued against restrictions.

The latest story lays out nine proposals that could reduce the drug’s toll, including lowering the maximum daily dose from 4 g (eight extra-strength pills) to 3 g (six pills); allowing only a single pediatric strength; removing acetaminophen from prescription opioids; restricting the number of pills consumers can buy at one time; and instructing those using extra-strength acetaminophen to start with one pill and increase to two if their pain does not improve.


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