As palmitoylethanolamide modifies overactive mast cells and reduce inflammation, this compound is a interesting treatment modality, see also http://www.dovepress.com/evolution-in-pharmacologic-thinking-around-the-natural-analgesic-palmi-peer-reviewed-article-JPR
J Neurogastroenterol Motil. 2013 Apr;19(2):244-50. doi: 10.5056/jnm.2013.19.2.244. Epub 2013 Apr 16.
BACKGROUND AIMS: Although mucosal mast cell tryptase is known to significantly increase intestinal permeability, the relationship between mucosal mast cells and intestinal permeability remains unclear. The objective of this study was to evaluate the correlation among intestinal permeability, tryptase activity and mucosal mast cell count.
Rectal biopsies from 16 patients with diarrhea-predominant irritable bowel syndrome (IBS-D) and 7 normal subjects were assessed for tryptase activity and macromolecular permeability using horseradish peroxidase in Ussing chambers. In addition, mucosal mast cell levels were immunohistochemically quantified via image analysis.
Rectal biopsy of tissues from IBS-D patients…
View original post 126 more words