Mucosal mast cell count is associated with intestinal permeability in patients with diarrhea predominant irritable bowel syndrome

As palmitoylethanolamide modifies overactive mast cells and reduce inflammation, this compound is a interesting treatment modality, see also

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J Neurogastroenterol Motil. 2013 Apr;19(2):244-50. doi: 10.5056/jnm.2013.19.2.244. Epub 2013 Apr 16.

Lee H, Park JH, Park DI, Kim HJ, Cho YK, Sohn CI, Jeon WK, Kim BI, Chae SW, Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea


BACKGROUND AIMS: Although mucosal mast cell tryptase is known to significantly increase intestinal permeability, the relationship between mucosal mast cells and intestinal permeability remains unclear. The objective of this study was to evaluate the correlation among intestinal permeability, tryptase activity and mucosal mast cell count.


Rectal biopsies from 16 patients with diarrhea-predominant irritable bowel syndrome (IBS-D) and 7 normal subjects were assessed for tryptase activity and macromolecular permeability using horseradish peroxidase in Ussing chambers. In addition, mucosal mast cell levels were immunohistochemically quantified via image analysis.


Rectal biopsy of tissues from IBS-D patients…

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