Palmitoylethanolamide (PEA) in the treatment of Cannabis dependency.

Drs M. Coppola and R. Mondola from the Department of Addiction, in Alba, Italy and the Department of Mental Health, Saluzzo, Italy published an interesting paper on the putative use of palmitoylethanolamide (PEA) in the treatment of Cannabis dependency.

They bring forward this hypothesis based on a variety of findings, They point out that like cannabis, evidences suggest that PEA, as THC, has anti-inflammatory and anti-nociceptive activity in humans as well as in animal models. PEA, an anandamide congener, might have PEA has anti-craving effects in cannabis dependent patients, is efficacious in the treatment of withdrawal symptoms, produces a reduction of cannabis consumption and is effective in the prevention of cannabis induced neurotoxicity and neuro-psychiatric disorders due to its pleotropic mechanism of action.


Coppola M, Mondola R. Palmitoylethanolamide: From endogenous cannabimimetic substance to innovative medicine for the treatment of cannabis dependence. Med Hypotheses. 2013 Jul 26. doi:pii: S0306-9877(13)00338-1.

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