In the above paper an important new piece of information has been disclosed; PEA has been evaluated up to 100 mg/kg BW and was found to be safe:
Dose recommendation PEA (PeaPure, Normast)
First 4 weeks dose 1200 mg/day
If not enough response double the dose after 4 weeks for another month.
If good response, reduce dose after 4 weeks to see what dose keeps you stable
If response is not as expected, stop PEA after 8 weeks, it is unlikely to kick in in the majority of patients when they have been on PEA for 8 weeks.