Neuroinflammation: relevant for the generation of neuropathic pain

Neuropathic pain is partly due to neuroinflammation, one of the reason to consider palmitoylethanolamide as a therapy.

Diverse causes of neuropathic pain are associated with excessive inflammation in both the peripheral and central nervous system which may contribute to the initiation and maintenance of persistent pain.

This is a quote from a recent 2013 paper, bearing the title:

Neuroinflammation and the generation of neuropathic pain

In this paper the authors explain how important inflammation is in neuropathic pain:

Chemical mediators, such as cytokines, chemokines, and lipid mediators, released during an inflammatory response have the undesired effect of sensitizing and stimulating nociceptors, their central synaptic targets or both. These changes can promote long-term maladaptive plasticity resulting in persistent neuropathic pain.

They end stating:

Targeting excessive inflammation in neuropathic pain provides potential therapeutic opportunities

This is exact the reason why the anti-inflammatory and analgesic supplement palmitoylethanolamide (PeaPure, een PEA-houdend product) needs to be taken into consideration.

Ellis A, Bennett DL. Neuroinflammation and the generation of neuropathic pain. Br J Anaesth. 2013 Jul;111(1):26-37. doi: 10.1093/bja/aet128.

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