Palmitoyethanolamide, a lipid metabolite and autocoid mediator: new chapter

Yun Michael Shim M.D. wrote an elaborate edotorial on autocoids, title:

Anticipated Scientific Contributions of the Lipid Metabolite Autacoids in
the Era of Metabolomics.

Palmitoylethanolamide has been identified as an autocoid by Levi-Montalcini in 1992-1996.

Shim says:

As we celebrate the ten-year anniversary of the post-genomic era,
lipid metabolites, a subset of the autacoid mediators, are now poised to
play a substantial role within the metabolomics strategy.

Metabolites participate  in extensive lists of cellular function, and the production of metabolites
in cells is usually the final outcome of the genomic, transcriptional and
translational variants. Thus, the analyses of metabolites can be envisioned
as the most integrated effort to assess the biologic mechanisms of action
involving the pathogenesis of human diseases. Recently substantial
advances in the technologies have enabled simultaneous identification,
quantification and characterization of a large number of metabolites
including intra- and extra-cellular signaling molecules, amino acid and
carbohydrate metabolism products and lipid metabolites. These efforts
collectively are now referred as “metabolomics”.

A substantial number of these metabolites  are a part of the mediators classified within the autacoid families.

And:

a subset of the autacoid mediators, are now poised to
play a substantial role within the metabolomics strategy.

Palmitoylethanolamide will be one of those autocoids.

Source:

Shim YM (2012) Anticipated Scientific Contributions of the Lipid Metabolite Autacoids in the Era of Metabolomics. J Autacoids 1:e117.
doi:10.4172/2161-0479.1000e117

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