N-Palmitoylethanolamine: A Broad-Acting Anti-inflammatory and Neuroprotective Lipid Mediator

In a new review article (2013) Dr Skraper regfers to PEA as a Broad-Acting Anti-inflammatory and Neuroprotective Lipid Mediator.  He discusses all data related to PEA over the last decade and concludes:

The capacity of PEA to modulate the protective responses of animals during inflammation and pain led to the hypothesis that endogenous PEA may be a component of the complex homeostatic system controlling the basal threshold of both inflammation and pain. The production of PEA during inflammatory conditions supports this role, and emerging data that selective inhibition of PEA degradation is antiinflammatory provides more direct evidence for the involvement of PEA in the control of pain and inflammation. As an endogenous compound, PEA has no adverse effects at pharmacological doses, while possessing a double therapeutic effect (i.e., anti-inflammatory and anti-nociceptive).

His final summary is:

PEA, its analogues, and agents that inhibit specifically its degradation are likely to result in the development of new therapeutic strategies for the treatment of pathological conditions where neuroinflammation is a factor

 

Source: Skaper SD, Facci L, Giusti P. Glia and Mast Cells as Targets for Palmitoylethanolamide, an Anti-inflammatory and Neuroprotective Lipid Mediator. Mol Neurobiol. 2013 Jun 28.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

%d bloggers like this: