Palmitoylethanolamide Is a Disease-Modifying Agent in Peripheral Neuropathy: Pain Relief and Neuroprotection Share a PPAR-Alpha-Mediated Mechanism

L. Di Cesare Mannelli and colleagues studied the mechanism of action of PEA in a sciatic pain model and published their findings in an open access Journal:

Mediators of Inflammation
Volume 2013 (2013), Article ID 328797, 12 pages
http://dx.doi.org/10.1155/2013/328797

under the titel:

Palmitoylethanolamide Is a Disease-Modifying Agent in Peripheral Neuropathy: Pain Relief and Neuroprotection Share a PPAR-Alpha-Mediated Mechanism.

In the attachment the PDF of this important article.

The conclusion was:

The present results demonstrate the neuroprotective properties of PEA in a preclinical model of neuropathic pain. Antihyperalgesic and neuroprotective properties are related to the anti-inflammatory effect of PEA and its ability to prevent macrophage infiltration in the nerve. 

2013-Palmitoylethanolamide Is a Disease-Modifying Agent in Peripheral Neuropathy- Pain Relief and Neuroprotection Share a PPAR-Alpha-Mediated Mechanism

 

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