L. Di Cesare Mannelli and colleagues studied the mechanism of action of PEA in a sciatic pain model and published their findings in an open access Journal:
Mediators of Inflammation Volume 2013 (2013), Article ID 328797, 12 pages http://dx.doi.org/10.1155/2013/328797
under the titel:
Palmitoylethanolamide Is a Disease-Modifying Agent in Peripheral Neuropathy: Pain Relief and Neuroprotection Share a PPAR-Alpha-Mediated Mechanism.
In the attachment the PDF of this important article.
The conclusion was:
The present results demonstrate the neuroprotective properties of PEA in a preclinical model of neuropathic pain. Antihyperalgesic and neuroprotective properties are related to the anti-inflammatory effect of PEA and its ability to prevent macrophage infiltration in the nerve.