Platelet by-products contains endogenous protective factors physiologically involved in wound healing, and under inflammatory conditions, Platelet Rich Plasma (PRP) induced the production of these compounds; palmitoylethanolamide is one of the more prominent of these protective factors.
PRP seems to produce these compounds, suggesting that PRP might induce the production of these analgesic mediators particularly in physiologically inflamed wounded tissue.
A PRP lipid extract showed a dose-related anti-nociceptive activity, and locally injected CB1, CB2 or TRPV1 receptor antagonists abolished the anti-nociceptive activity of the PRP extract, both on the early and late phase of the response.
The conclusion of the authors was that PRP and PRP lipid extract exert a potent anti-nociceptive activity linked, at least in part, to their bio-active lipids and related compounds content, and to their capability of elevating the levels of these lipid mediators in cells.
This study again demonstrates the important regenerative and tissue-engineering effects of endogenous lipids such as PEA.
PEA also appeared to be present in the highest concentration in PRP.
Descalzi F, Ulivi V, Cancedda R, Piscitelli F, Luongo L, Guida F, Gatta L, Maione S, Di Marzo V.
Platelet Rich Plasma exerts anti-nociceptive activity by a peripheral endocannabinoid-related mechanism. Tissue Eng Part A. 2013 Apr 12.